FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3167961233> ?p ?o ?g. }

• W3167961233 abstract "Pneumocystis species colonize mammalian lungs and cause deadly pneumonia if the immune system of the host weakens. Each species presents a specificity for a single mammalian host species. Pneumocystis jirovecii infects humans and provokes pneumonia, which is among the most frequent invasive fungal infections. The lack of in vitro culture methods for these fungi complicates their study. Recently, high-throughput sequencing technologies followed by comparative genomics have allowed a better understanding of the mechanisms involved in the sexuality of Pneumocystis organisms. The structure of their mating-type locus corresponding to a fusion of two loci, Plus and Minus, and the concomitant expression of the three mating-type genes revealed that their mode of sexual reproduction is primarily homothallism. This mode is favored by microbial pathogens and involves a single self-compatible mating type that can enter into the sexual cycle on its own. Pneumocystis sexuality is obligatory within the host's lungs during pneumonia in adults, primary infection in children, and possibly colonization. This sexuality participates in cell proliferation, airborne transmission to new hosts, and probably antigenic variation, processes that are crucial to ensure the survival of the fungus. Thus, sexuality is central in the Pneumocystis life cycle. The obligate biotrophic parasitism with obligate sexuality of Pneumocystis is unique among fungi pathogenic to humans. Pneumocystis organisms are similar to the plant fungal obligate biotrophs that complete their entire life cycle within their hosts, including sex, and that are also difficult to grow in vitro." @default.
• W3167961233 created "2021-06-22" @default.
• W3167961233 creator A5005230621 @default.
• W3167961233 date "2021-08-18" @default.
• W3167961233 modified "2023-10-13" @default.
• W3167961233 title "Pneumocystis Mating-Type Locus and Sexual Cycle during Infection" @default.
• W3167961233 cites W1966382332 @default.
• W3167961233 cites W1966537104 @default.
• W3167961233 cites W1968109336 @default.
• W3167961233 cites W1970453278 @default.
• W3167961233 cites W1973614613 @default.
• W3167961233 cites W1977858953 @default.
• W3167961233 cites W1981692280 @default.
• W3167961233 cites W1982146118 @default.
• W3167961233 cites W1982946985 @default.
• W3167961233 cites W1985920554 @default.
• W3167961233 cites W1989445468 @default.
• W3167961233 cites W1989989006 @default.
• W3167961233 cites W2007116653 @default.
• W3167961233 cites W2027180419 @default.
• W3167961233 cites W2027366126 @default.
• W3167961233 cites W2037686178 @default.
• W3167961233 cites W2042668526 @default.
• W3167961233 cites W2051993728 @default.
• W3167961233 cites W2061856842 @default.
• W3167961233 cites W2068673861 @default.
• W3167961233 cites W2078734228 @default.
• W3167961233 cites W2080900647 @default.
• W3167961233 cites W2084426314 @default.
• W3167961233 cites W2091452413 @default.
• W3167961233 cites W2094353613 @default.
• W3167961233 cites W2098417232 @default.
• W3167961233 cites W2099010651 @default.
• W3167961233 cites W2104930358 @default.
• W3167961233 cites W2107794472 @default.
• W3167961233 cites W2107993592 @default.
• W3167961233 cites W2111198090 @default.
• W3167961233 cites W2115344398 @default.
• W3167961233 cites W2115840843 @default.
• W3167961233 cites W2118096303 @default.
• W3167961233 cites W2118968520 @default.
• W3167961233 cites W2129014166 @default.
• W3167961233 cites W2129088508 @default.
• W3167961233 cites W2130479481 @default.
• W3167961233 cites W2130532765 @default.
• W3167961233 cites W2146158783 @default.
• W3167961233 cites W2149286475 @default.
• W3167961233 cites W2149307555 @default.
• W3167961233 cites W2154646844 @default.
• W3167961233 cites W2156592409 @default.
• W3167961233 cites W2164938934 @default.
• W3167961233 cites W2165642973 @default.
• W3167961233 cites W2167247952 @default.
• W3167961233 cites W2168747497 @default.
• W3167961233 cites W2169540909 @default.
• W3167961233 cites W2288062690 @default.
• W3167961233 cites W2401764344 @default.
• W3167961233 cites W2421629064 @default.
• W3167961233 cites W2467938883 @default.
• W3167961233 cites W2602814871 @default.
• W3167961233 cites W2610324632 @default.
• W3167961233 cites W2754400687 @default.
• W3167961233 cites W2755946618 @default.
• W3167961233 cites W2767522314 @default.
• W3167961233 cites W2770264279 @default.
• W3167961233 cites W2789955800 @default.
• W3167961233 cites W2791106942 @default.
• W3167961233 cites W2888305097 @default.
• W3167961233 cites W2902958487 @default.
• W3167961233 cites W2944437597 @default.
• W3167961233 cites W2949176546 @default.
• W3167961233 cites W2956865216 @default.
• W3167961233 cites W3006983638 @default.
• W3167961233 cites W3019842671 @default.
• W3167961233 cites W3036142514 @default.
• W3167961233 cites W3085976277 @default.
• W3167961233 cites W4210576730 @default.
• W3167961233 cites W4247829572 @default.
• W3167961233 cites W789974345 @default.
• W3167961233 doi "https://doi.org/10.1128/mmbr.00009-21" @default.
• W3167961233 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8483669" @default.
• W3167961233 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34132101" @default.
• W3167961233 hasPublicationYear "2021" @default.
• W3167961233 type Work @default.
• W3167961233 sameAs 3167961233 @default.
• W3167961233 citedByCount "7" @default.
• W3167961233 countsByYear W31679612332021 @default.
• W3167961233 countsByYear W31679612332022 @default.
• W3167961233 crossrefType "journal-article" @default.
• W3167961233 hasAuthorship W3167961233A5005230621 @default.
• W3167961233 hasBestOaLocation W31679612331 @default.
• W3167961233 hasConcept C104317684 @default.
• W3167961233 hasConcept C126831891 @default.
• W3167961233 hasConcept C159047783 @default.
• W3167961233 hasConcept C159575461 @default.
• W3167961233 hasConcept C18903297 @default.
• W3167961233 hasConcept C198348125 @default.
• W3167961233 hasConcept C24990904 @default.
• W3167961233 hasConcept C2777160144 @default.
• W3167961233 hasConcept C2777559004 @default.

• next