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• W3168021204 abstract "Abstract Objectives To discuss the opportunities and challenges when applying an electronic record linkage methodology with respect to systemic anti-cancer therapy, and to highlight some of the potential pitfalls spanning the entire breadth and depth of the research process. Design Retrospective cohort studies using routinely collected, administrative health data. Setting: Scotland Results Studies conducted to-date have indicated that record linkage of routinely collected data to determine outcomes of treatment with cancer medicines is feasible, albeit currently within certain limits. While the general description of patient populations and the calculation of median overall survival are well supported, prevailing issues with combining data across regional boundaries and the limited availability of some variables (including molecular pathology data and information regarding toxicities) may restrict the extent of analyses feasible. Conclusion There is scope to conduct large cohort studies to generate results from clinical practice using linkage of routinely collected health care data within a reasonable time frame; however, close collaboration between researchers, data controllers, and clinicians is required in order to obtain valid and meaningful results. Article Summary Strengths and limitations of this study This is the first description of a comprehensive programme aimed at evaluating the feasibility of linking routinely collected health data to evaluate the outcomes of systemic anti-cancer treatment in clinical practice. The multi-disciplinary study team comprised both academics and clinicians, with a wide range of skills, expertise, and experience. While a number of studies focusing on different cancers have successfully been conducted, not all research questions of interest could be fully answered due to some existing data gaps. Nevertheless, study findings have been discussed with health care professionals across Scotland, and have started to have an impact on shared patient-clinical decision making." @default.
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• W3168021204 date "2021-06-04" @default.
• W3168021204 modified "2023-10-15" @default.
• W3168021204 title "Opportunities and challenges when using record linkage of routinely collected electronic health care data to evaluate outcomes of systemic anti-cancer treatment in clinical practice" @default.
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• W3168021204 doi "https://doi.org/10.1101/2021.05.28.21257611" @default.
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