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- W3168122116 abstract "Abstract An enduring problem in biology is explaining how novel functions of genes originated and how those functions diverge between species. Despite detailed studies on the functional evolution of a few proteins, the molecular mechanisms by which protein functions have evolved are almost entirely unknown. Here, we show that a polyalanine tract in the homeodomain transcription factor HoxA11 arose in the stem‐lineage of mammals and functions as an autonomous repressor module by physically interacting with the PAH domains of SIN3 proteins. These results suggest that long polyalanine tracts, which are common in transcription factors and often associated with disease, may tend to function as repressor domains and can contribute to the diversification of transcription factor functions despite the deleterious consequences of polyalanine tract expansion." @default.
- W3168122116 created "2021-06-22" @default.
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- W3168122116 date "2021-06-14" @default.
- W3168122116 modified "2023-10-14" @default.
- W3168122116 title "Cooption of polyalanine tract into a repressor domain in the mammalian transcription factor HoxA11" @default.
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- W3168122116 doi "https://doi.org/10.1002/jez.b.23063" @default.
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