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- W3168122831 abstract "Due to its size, shape, and inherent expression of pathogen-associated molecular patterns and invasion-assistant adhesion proteins , Burkholderia pseudomallei can easily attach to, and then be internalized by, dendritic cells (DCs), leading to more efficient antigen cross-presentation if modified as carrier. Herein, we engineered Burkholderia pseudomallei as a porous/hollow carrier (SB) for loading tumor lysates (L) and adjuvant CpG (C) to be used as a tumor vaccine (SB-LC). We found that the adhesion proteins of Burkholderia pseudomallei promote internalization of the SB-LC vaccine by DCs, and result in enhanced DC maturation and antigen cross-presentation. SB-LC induces robust cellular and humoral antitumor responses that synergistically inhibit tumor growth with minimal adverse side effects in several tumor models. Moreover, SB-LC vaccination reverses the immunosuppressive tumor microenvironment , apparently as a result of CD8 + -induced tumor ferroptosis . Thus, SB-LC is a potential model tumor vaccine for translating into a clinically viable treatment option." @default.
- W3168122831 created "2021-06-22" @default.
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- W3168122831 date "2021-11-01" @default.
- W3168122831 modified "2023-10-18" @default.
- W3168122831 title "Engineered porous/hollow Burkholderia pseudomallei loading tumor lysate as a vaccine" @default.
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- W3168122831 doi "https://doi.org/10.1016/j.biomaterials.2021.121141" @default.
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