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- W3168127142 abstract "During exercise, an old age-associated inability to increase vascular resistance within intra-abdominal adipose tissue (AT) may compromise the ability to redistribute blood flow. We tested the hypotheses that 1) there would be an elevated perfusion of AT during exercise with old age, associated with diminished arterial vasoconstrictor responses, and 2) exercise training (ET) would mitigate age-associated alterations in AT blood flow. Young (Y, 6 mo; n=40) and old (O, 24 mo; n=28) male Fischer 344 rats were divided into sedentary (YSed, OSed) or ET (YET, OET, 10wks treadmill exercise) groups. Blood flow at rest and during exercise and α-adrenergic and myogenic vasoconstrictor responses in resistance arteries from AT were measured. During exercise there was a directionally opposite AT blood flow response in OSed group (~150% increase) and YSed (~ 55% decrease) versus resting values. Both α-adrenergic and myogenic vasoconstriction were diminished in OSed versus YSed. ET resulted in a similar AT hyperemic response between age groups during exercise (YET, 10 ± 1; OET, 8 ± 1 ml/min/100 g) and was associated with enhanced myogenic and α-adrenergic vasoconstriction in AT arteries from the OET group relative to OSed. These results indicate that there is an inability to increase vascular resistance in AT during exercise with old age due, in part, to a diminished vasoconstriction in AT arteries." @default.
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- W3168127142 date "2013-04-01" @default.
- W3168127142 modified "2023-09-27" @default.
- W3168127142 title "Differential effects of aging and exercise training on intra‐abdominal adipose arteriolar function and blood flow regulation" @default.
- W3168127142 doi "https://doi.org/10.1096/fasebj.27.1_supplement.898.6" @default.
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