Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168157443> ?p ?o ?g. }
- W3168157443 endingPage "7" @default.
- W3168157443 startingPage "1" @default.
- W3168157443 abstract "Patients with obsessive-compulsive disorder (OCD) experience deficiencies in reward processing. The investigation of the reward circuit and its essential connectivity may further clarify the pathogenesis of OCD.The current research was designed to analyze the nucleus accumbens (NAc) functional connectivity at rest in medicine-free patients with OCD. Forty medication-free patients and 38 gender-, education-, and age-matched healthy controls (HCs) were recruited for resting-state functional magnetic resonance imaging. Seed-based functional connectivity (FC) was used to analyze the data. LIBSVM (library for support vector machines) was designed to identify whether altered FC could be applied to differentiate OCD.Patients with OCD showed remarkably decreased FC values between the left NAc and the bilateral orbitofrontal cortex (OFC) and bilateral medial prefrontal cortex (MPFC) and between the right NAc and the left OFC at rest in the reward circuit. Moreover, decreased left NAc-bilateral MPFC connectivity can be deemed as a potential biomarker to differentiate OCD from HCs with a sensitivity of 80.00% and a specificity of 76.32%.The current results emphasize the importance of the reward circuit in the pathogenesis of OCD." @default.
- W3168157443 created "2021-06-22" @default.
- W3168157443 creator A5004716253 @default.
- W3168157443 creator A5011104783 @default.
- W3168157443 creator A5011995859 @default.
- W3168157443 creator A5015292871 @default.
- W3168157443 creator A5018031930 @default.
- W3168157443 creator A5019597107 @default.
- W3168157443 creator A5019829518 @default.
- W3168157443 creator A5021705916 @default.
- W3168157443 creator A5022632302 @default.
- W3168157443 creator A5034036164 @default.
- W3168157443 creator A5044812188 @default.
- W3168157443 creator A5063367521 @default.
- W3168157443 creator A5080278772 @default.
- W3168157443 creator A5087887288 @default.
- W3168157443 creator A5089812226 @default.
- W3168157443 date "2021-06-01" @default.
- W3168157443 modified "2023-10-01" @default.
- W3168157443 title "Decreased Nucleus Accumbens Connectivity at Rest in Medication-Free Patients with Obsessive-Compulsive Disorder" @default.
- W3168157443 cites W1922107730 @default.
- W3168157443 cites W1944839424 @default.
- W3168157443 cites W195737476 @default.
- W3168157443 cites W1967297724 @default.
- W3168157443 cites W1975528635 @default.
- W3168157443 cites W1979906070 @default.
- W3168157443 cites W1990134753 @default.
- W3168157443 cites W1993315944 @default.
- W3168157443 cites W2012440798 @default.
- W3168157443 cites W2025985542 @default.
- W3168157443 cites W2026740841 @default.
- W3168157443 cites W2057821678 @default.
- W3168157443 cites W2067008343 @default.
- W3168157443 cites W2069090835 @default.
- W3168157443 cites W2073718251 @default.
- W3168157443 cites W2074174736 @default.
- W3168157443 cites W2079663832 @default.
- W3168157443 cites W2098053517 @default.
- W3168157443 cites W2100861230 @default.
- W3168157443 cites W2101568283 @default.
- W3168157443 cites W2104886804 @default.
- W3168157443 cites W2110899801 @default.
- W3168157443 cites W2120090250 @default.
- W3168157443 cites W2126144658 @default.
- W3168157443 cites W2128789082 @default.
- W3168157443 cites W2131049151 @default.
- W3168157443 cites W2132741811 @default.
- W3168157443 cites W2135018980 @default.
- W3168157443 cites W2146699327 @default.
- W3168157443 cites W2146933933 @default.
- W3168157443 cites W2148460095 @default.
- W3168157443 cites W2190763606 @default.
- W3168157443 cites W2337323496 @default.
- W3168157443 cites W2512901722 @default.
- W3168157443 cites W2885869681 @default.
- W3168157443 cites W2909079388 @default.
- W3168157443 cites W2954874978 @default.
- W3168157443 cites W2963906785 @default.
- W3168157443 cites W2966149403 @default.
- W3168157443 cites W2977775670 @default.
- W3168157443 doi "https://doi.org/10.1155/2021/9966378" @default.
- W3168157443 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8187042" @default.
- W3168157443 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34158811" @default.
- W3168157443 hasPublicationYear "2021" @default.
- W3168157443 type Work @default.
- W3168157443 sameAs 3168157443 @default.
- W3168157443 citedByCount "5" @default.
- W3168157443 countsByYear W31681574432021 @default.
- W3168157443 countsByYear W31681574432022 @default.
- W3168157443 countsByYear W31681574432023 @default.
- W3168157443 crossrefType "journal-article" @default.
- W3168157443 hasAuthorship W3168157443A5004716253 @default.
- W3168157443 hasAuthorship W3168157443A5011104783 @default.
- W3168157443 hasAuthorship W3168157443A5011995859 @default.
- W3168157443 hasAuthorship W3168157443A5015292871 @default.
- W3168157443 hasAuthorship W3168157443A5018031930 @default.
- W3168157443 hasAuthorship W3168157443A5019597107 @default.
- W3168157443 hasAuthorship W3168157443A5019829518 @default.
- W3168157443 hasAuthorship W3168157443A5021705916 @default.
- W3168157443 hasAuthorship W3168157443A5022632302 @default.
- W3168157443 hasAuthorship W3168157443A5034036164 @default.
- W3168157443 hasAuthorship W3168157443A5044812188 @default.
- W3168157443 hasAuthorship W3168157443A5063367521 @default.
- W3168157443 hasAuthorship W3168157443A5080278772 @default.
- W3168157443 hasAuthorship W3168157443A5087887288 @default.
- W3168157443 hasAuthorship W3168157443A5089812226 @default.
- W3168157443 hasBestOaLocation W31681574431 @default.
- W3168157443 hasConcept C118552586 @default.
- W3168157443 hasConcept C15744967 @default.
- W3168157443 hasConcept C169760540 @default.
- W3168157443 hasConcept C169900460 @default.
- W3168157443 hasConcept C2776552330 @default.
- W3168157443 hasConcept C2776559556 @default.
- W3168157443 hasConcept C2781195155 @default.
- W3168157443 hasConcept C3017582312 @default.
- W3168157443 hasConcept C3018011982 @default.
- W3168157443 hasConcept C513476851 @default.
- W3168157443 hasConcept C66324658 @default.