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- W3168160911 abstract "Abstract While viremia in the vertebrate host is a major determinant of arboviral reservoir competency, transmission efficiency, and disease severity, immune mechanisms that control arboviral viremia are poorly defined. Here, we identify critical roles for the scavenger receptor MARCO in controlling viremia during arthritogenic alphavirus infections in mice. Following subcutaneous inoculation, alphavirus particles drain via the lymph and are rapidly captured by MARCO + lymphatic endothelial cells (LECs) in the draining lymph node (dLN), limiting viral spread to the bloodstream. Upon reaching the bloodstream, alphavirus particles are cleared from the circulation by MARCO-expressing Kupffer cells in the liver, limiting viremia and further viral dissemination. MARCO-mediated accumulation of alphavirus particles in the dLN and liver is an important host defense mechanism as viremia and viral tissue burdens are elevated in MARCO -/- mice and disease is more severe. These findings uncover a previously unrecognized arbovirus scavenging role for LECs and improve our mechanistic understanding of viremia control during arboviral infections." @default.
- W3168160911 created "2021-06-22" @default.
- W3168160911 creator A5004079262 @default.
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- W3168160911 creator A5014015685 @default.
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- W3168160911 creator A5060930429 @default.
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- W3168160911 creator A5080481359 @default.
- W3168160911 date "2021-06-10" @default.
- W3168160911 modified "2023-10-15" @default.
- W3168160911 title "MARCO+ lymphatic endothelial cells sequester arboviruses to limit viremia and viral dissemination" @default.
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