FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168161719> ?p ?o ?g. }

• W3168161719 endingPage "S585" @default.
• W3168161719 startingPage "S584" @default.
• W3168161719 abstract "Abstract Background Studies suggest that complex cryptoglandular fistulas (CCF) are difficult to treat, resulting in higher intervention failure rates and functional disability. This systematic literature review (SLR) assessed the epidemiology of cryptoglandular fistula and outcomes associated with local, surgical and intersphincteric ligation procedures for treatment of CCF. Methods PubMed and Embase were searched to identify articles published in the past 5 years (2015–2020) relating to incidence or prevalence of cryptoglandular fistula and outcomes of surgical interventions for CCF (PROSPERO registration number CRD42020177732). Outcomes of interest included fistula closure/healing, recurrence, surgery failure, post-operative pain and faecal incontinence. The interventions included anal flap procedures, fistulectomy, fistulotomy, primary sphincteroplasty, modified Park’s technique, LIFT or BIOLIFT, and TROPIS. Two trained reviewers used pre-specified eligibility criteria to identify studies for inclusion and evaluate risk of bias using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool for observational studies. Data were extracted for a range of variables, including study type and design, population, outcomes and limitations. Results In total, 148 studies were identified that met a priori eligibility criteria for all cryptoglandular fistulas and all intervention types. Of these, two reported incidence or prevalence of cryptoglandular fistulas and 18 reported outcomes for the interventions of interest in CCF. Prevalence of cryptoglandular fistulas was reported as 1.35 per 10 000 patients without Crohn’s disease, and 52.6% of patients without IBD were found to progress from anorectal abscess to fistula over 12 months. Studies examining the clinical outcomes reported primary healing rates of 57.4–100.0%, recurrence rates of 4.9–61.0% and failure rates of 2.8–18.0% of patients. Only five studies reported post-operative pain as a clinical outcome. Overall, these studies suggest patients experience no or minimal longer-term post-operative pain. In studies reporting post-operative faecal incontinence following anal mucosal flap procedures, observed incontinence rates were low, as measured using Wexner or Miller scoring. None of the studies involving fistulectomy measured faecal incontinence. Conclusion This SLR provides a summary of outcomes from a selected group of surgical interventions for CCF. Healing rates vary according to surgery type; however, differences in study design and heterogenous definitions prevent direct comparison. Overall, the published literature indicates low to modest rates of CCF recurrence and limited data on faecal incontinence and longer-term post-operative pain. Sponsor: Takeda Pharmaceuticals USA, Inc." @default.
• W3168161719 created "2021-06-22" @default.
• W3168161719 creator A5000045044 @default.
• W3168161719 creator A5004080250 @default.
• W3168161719 creator A5009089332 @default.
• W3168161719 creator A5048549352 @default.
• W3168161719 creator A5086794254 @default.
• W3168161719 date "2021-05-01" @default.
• W3168161719 modified "2023-09-27" @default.
• W3168161719 title "P656 Epidemiology and outcomes associated with local surgical and intersphincteric ligation procedures for complex cryptoglandular fistulas: A systematic literature review" @default.
• W3168161719 doi "https://doi.org/10.1093/ecco-jcc/jjab076.776" @default.
• W3168161719 hasPublicationYear "2021" @default.
• W3168161719 type Work @default.
• W3168161719 sameAs 3168161719 @default.
• W3168161719 citedByCount "0" @default.
• W3168161719 crossrefType "journal-article" @default.
• W3168161719 hasAuthorship W3168161719A5000045044 @default.
• W3168161719 hasAuthorship W3168161719A5004080250 @default.
• W3168161719 hasAuthorship W3168161719A5009089332 @default.
• W3168161719 hasAuthorship W3168161719A5048549352 @default.
• W3168161719 hasAuthorship W3168161719A5086794254 @default.
• W3168161719 hasBestOaLocation W31681617191 @default.
• W3168161719 hasConcept C118552586 @default.
• W3168161719 hasConcept C126322002 @default.
• W3168161719 hasConcept C141071460 @default.
• W3168161719 hasConcept C1862650 @default.
• W3168161719 hasConcept C23131810 @default.
• W3168161719 hasConcept C27415008 @default.
• W3168161719 hasConcept C2776341189 @default.
• W3168161719 hasConcept C2776929390 @default.
• W3168161719 hasConcept C2777887063 @default.
• W3168161719 hasConcept C71924100 @default.
• W3168161719 hasConceptScore W3168161719C118552586 @default.
• W3168161719 hasConceptScore W3168161719C126322002 @default.
• W3168161719 hasConceptScore W3168161719C141071460 @default.
• W3168161719 hasConceptScore W3168161719C1862650 @default.
• W3168161719 hasConceptScore W3168161719C23131810 @default.
• W3168161719 hasConceptScore W3168161719C27415008 @default.
• W3168161719 hasConceptScore W3168161719C2776341189 @default.
• W3168161719 hasConceptScore W3168161719C2776929390 @default.
• W3168161719 hasConceptScore W3168161719C2777887063 @default.
• W3168161719 hasConceptScore W3168161719C71924100 @default.
• W3168161719 hasIssue "Supplement_1" @default.
• W3168161719 hasLocation W31681617191 @default.
• W3168161719 hasOpenAccess W3168161719 @default.
• W3168161719 hasPrimaryLocation W31681617191 @default.
• W3168161719 hasRelatedWork W155850415 @default.
• W3168161719 hasRelatedWork W1997791326 @default.
• W3168161719 hasRelatedWork W2026473218 @default.
• W3168161719 hasRelatedWork W2091930412 @default.
• W3168161719 hasRelatedWork W2899904072 @default.
• W3168161719 hasRelatedWork W2926070630 @default.
• W3168161719 hasRelatedWork W2942137395 @default.
• W3168161719 hasRelatedWork W2946782874 @default.
• W3168161719 hasRelatedWork W3203247764 @default.
• W3168161719 hasRelatedWork W3206313813 @default.
• W3168161719 hasVolume "15" @default.
• W3168161719 isParatext "false" @default.
• W3168161719 isRetracted "false" @default.
• W3168161719 magId "3168161719" @default.
• W3168161719 workType "article" @default.