FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168202391> ?p ?o ?g. }

• W3168202391 abstract "N-methyl-D-aspartate glutamate-receptor (NMDAR) antagonists such as ketamine have demonstrated efficacy in both major depressive disorder (MDD) and bipolar disorder depression (BP-D). We have previously reported that reduction in Glx (glutamate + glutamine) in the ventromedial prefrontal cortex/anterior cingulate cortex (vmPFC/ACC), measured by proton magnetic resonance spectroscopy ( 1 H MRS) at 3T during a ketamine infusion, mediates the relationship of ketamine dose and blood level to improvement in depression. In the present study, we assessed the impact of D -cycloserine (DCS), an oral NMDAR antagonist combined with lurasidone in BP-D on both glutamate and Glx. Subjects with DSM-V BP-D-I/II and a Montgomery-Asberg Depression Rating Scale (MADRS) score&gt;17, underwent up to three 1 H MRS scans. During Scan 1, subjects were randomized to receive double-blind lurasidone 66 mg or placebo. During Scan 2, all subjects received single-blind DCS 950 mg + lurasidone 66 mg, followed by 4 weeks of open label phase of DCS+lurasidone and an optional Scan 3. Five subjects received lurasidone alone and three subjects received placebo for Scan 1. Six subjects received DCS+lurasidone during Scan 2. There was no significant baseline or between treatment-group differences in acute depression improvement or glutamate response. In Scan 2, after a dose of DCS+lurasidone, peak change in glutamate correlated negatively with improvement from baseline MADRS (r = −0.83, p = 0.04). There were no unexpected adverse events. These preliminary pilot results require replication but provide further support for a link between antidepressant effect and a decrease in glutamate by the NMDAR antagonist class of antidepressants." @default.
• W3168202391 created "2021-06-22" @default.
• W3168202391 creator A5002562154 @default.
• W3168202391 creator A5006873713 @default.
• W3168202391 creator A5008479872 @default.
• W3168202391 creator A5053352130 @default.
• W3168202391 creator A5056208693 @default.
• W3168202391 creator A5061929421 @default.
• W3168202391 creator A5069359388 @default.
• W3168202391 creator A5086344811 @default.
• W3168202391 creator A5090507160 @default.
• W3168202391 date "2021-06-02" @default.
• W3168202391 modified "2023-10-16" @default.
• W3168202391 title "Relationship of Brain Glutamate Response to D-Cycloserine and Lurasidone to Antidepressant Response in Bipolar Depression: A Pilot Study" @default.
• W3168202391 cites W1557128794 @default.
• W3168202391 cites W1846441878 @default.
• W3168202391 cites W1914381346 @default.
• W3168202391 cites W1966977193 @default.
• W3168202391 cites W1969919708 @default.
• W3168202391 cites W1971460793 @default.
• W3168202391 cites W1982062069 @default.
• W3168202391 cites W2039742348 @default.
• W3168202391 cites W2040456345 @default.
• W3168202391 cites W2049095127 @default.
• W3168202391 cites W2058027749 @default.
• W3168202391 cites W2058562945 @default.
• W3168202391 cites W2062229924 @default.
• W3168202391 cites W2066042423 @default.
• W3168202391 cites W2072691242 @default.
• W3168202391 cites W2073738730 @default.
• W3168202391 cites W2075720111 @default.
• W3168202391 cites W2080031358 @default.
• W3168202391 cites W2086267010 @default.
• W3168202391 cites W2090175734 @default.
• W3168202391 cites W2092896191 @default.
• W3168202391 cites W2103255996 @default.
• W3168202391 cites W2107950329 @default.
• W3168202391 cites W2131823335 @default.
• W3168202391 cites W2140334213 @default.
• W3168202391 cites W2145141773 @default.
• W3168202391 cites W2146645762 @default.
• W3168202391 cites W2163368530 @default.
• W3168202391 cites W2268317504 @default.
• W3168202391 cites W2375106168 @default.
• W3168202391 cites W2466842153 @default.
• W3168202391 cites W254805310 @default.
• W3168202391 cites W2558858359 @default.
• W3168202391 cites W2596902563 @default.
• W3168202391 cites W2608506675 @default.
• W3168202391 cites W2768172955 @default.
• W3168202391 cites W2770367203 @default.
• W3168202391 cites W2771797851 @default.
• W3168202391 cites W2898063298 @default.
• W3168202391 cites W2907944614 @default.
• W3168202391 cites W2921930118 @default.
• W3168202391 cites W2933289315 @default.
• W3168202391 cites W2948816951 @default.
• W3168202391 cites W2962457753 @default.
• W3168202391 cites W2969121736 @default.
• W3168202391 cites W3013097214 @default.
• W3168202391 cites W3014355680 @default.
• W3168202391 cites W3024809249 @default.
• W3168202391 cites W3048755251 @default.
• W3168202391 cites W3082360571 @default.
• W3168202391 cites W3112060037 @default.
• W3168202391 cites W3126982861 @default.
• W3168202391 cites W3155984011 @default.
• W3168202391 cites W834047622 @default.
• W3168202391 doi "https://doi.org/10.3389/fpsyt.2021.653026" @default.
• W3168202391 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8208505" @default.
• W3168202391 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34149476" @default.
• W3168202391 hasPublicationYear "2021" @default.
• W3168202391 type Work @default.
• W3168202391 sameAs 3168202391 @default.
• W3168202391 citedByCount "7" @default.
• W3168202391 countsByYear W31682023912021 @default.
• W3168202391 countsByYear W31682023912022 @default.
• W3168202391 countsByYear W31682023912023 @default.
• W3168202391 crossrefType "journal-article" @default.
• W3168202391 hasAuthorship W3168202391A5002562154 @default.
• W3168202391 hasAuthorship W3168202391A5006873713 @default.
• W3168202391 hasAuthorship W3168202391A5008479872 @default.
• W3168202391 hasAuthorship W3168202391A5053352130 @default.
• W3168202391 hasAuthorship W3168202391A5056208693 @default.
• W3168202391 hasAuthorship W3168202391A5061929421 @default.
• W3168202391 hasAuthorship W3168202391A5069359388 @default.
• W3168202391 hasAuthorship W3168202391A5086344811 @default.
• W3168202391 hasAuthorship W3168202391A5090507160 @default.
• W3168202391 hasBestOaLocation W31682023911 @default.
• W3168202391 hasConcept C118552586 @default.
• W3168202391 hasConcept C126322002 @default.
• W3168202391 hasConcept C142724271 @default.
• W3168202391 hasConcept C15744967 @default.
• W3168202391 hasConcept C169900460 @default.
• W3168202391 hasConcept C170493617 @default.
• W3168202391 hasConcept C204787440 @default.
• W3168202391 hasConcept C27081682 @default.
• W3168202391 hasConcept C2776174506 @default.
• W3168202391 hasConcept C2776412080 @default.
• W3168202391 hasConcept C2776592573 @default.

• next