Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168204505> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W3168204505 abstract "We examined a new hypothesis that the tissue expressions of TLRs/NLRs/inflammasome/caspase-1/IL-1β pathway are differentially regulated. We made several findings: (1) Vascular tissues and heart express fewer types of TLRs and NLRs than immune tissues; and (2) Based on the expression data of inflammasomes (NALP1, NALP3 and IPAF), the tissues can be classified into three tiers: the first tier tissues including blood and thymus express inflammasome(s) in constitutive status; the second tier tissues have inflammasome(s) in nearly-ready expression status (with the requirement of upregulation of one component); the third tier tissues, like heart, require upregulation of at least two components to assemble functional inflammasomes. We examined the mRNA levels of inflammasome components in human aortic endothelial cells after stimulated with lipopolysaccharide (LPS). In the presence of LPS stimulation, the mRNA levels of the main inflammasome component including ASC, caspase-1, NALP-1 and NALP-3 are up-regulated, which supports our three-tier model. Our original model of three-tier expression of inflammasomes would further suggest a new concept of tissues’ inflammation privilege, which provides an important insight to the differences among tissues in initiating acute inflammation and upregulation of inflammasomes in inflammation-privileged tissues in response to chronic metabolic stimuli." @default.
- W3168204505 created "2021-06-22" @default.
- W3168204505 creator A5014977626 @default.
- W3168204505 creator A5033020983 @default.
- W3168204505 creator A5033800255 @default.
- W3168204505 creator A5069971376 @default.
- W3168204505 creator A5076601235 @default.
- W3168204505 creator A5085025467 @default.
- W3168204505 date "2010-04-01" @default.
- W3168204505 modified "2023-10-17" @default.
- W3168204505 title "Three‐Tier Model for Inflammasome Expression and a New Concept of Inflammation Privilege" @default.
- W3168204505 doi "https://doi.org/10.1096/fasebj.24.1_supplement.476.8" @default.
- W3168204505 hasPublicationYear "2010" @default.
- W3168204505 type Work @default.
- W3168204505 sameAs 3168204505 @default.
- W3168204505 citedByCount "0" @default.
- W3168204505 crossrefType "journal-article" @default.
- W3168204505 hasAuthorship W3168204505A5014977626 @default.
- W3168204505 hasAuthorship W3168204505A5033020983 @default.
- W3168204505 hasAuthorship W3168204505A5033800255 @default.
- W3168204505 hasAuthorship W3168204505A5069971376 @default.
- W3168204505 hasAuthorship W3168204505A5076601235 @default.
- W3168204505 hasAuthorship W3168204505A5085025467 @default.
- W3168204505 hasConcept C104317684 @default.
- W3168204505 hasConcept C127561419 @default.
- W3168204505 hasConcept C136449434 @default.
- W3168204505 hasConcept C139964883 @default.
- W3168204505 hasConcept C162157009 @default.
- W3168204505 hasConcept C17172800 @default.
- W3168204505 hasConcept C203014093 @default.
- W3168204505 hasConcept C2776914184 @default.
- W3168204505 hasConcept C2777209026 @default.
- W3168204505 hasConcept C2778754761 @default.
- W3168204505 hasConcept C54355233 @default.
- W3168204505 hasConcept C86803240 @default.
- W3168204505 hasConcept C8891405 @default.
- W3168204505 hasConcept C95444343 @default.
- W3168204505 hasConceptScore W3168204505C104317684 @default.
- W3168204505 hasConceptScore W3168204505C127561419 @default.
- W3168204505 hasConceptScore W3168204505C136449434 @default.
- W3168204505 hasConceptScore W3168204505C139964883 @default.
- W3168204505 hasConceptScore W3168204505C162157009 @default.
- W3168204505 hasConceptScore W3168204505C17172800 @default.
- W3168204505 hasConceptScore W3168204505C203014093 @default.
- W3168204505 hasConceptScore W3168204505C2776914184 @default.
- W3168204505 hasConceptScore W3168204505C2777209026 @default.
- W3168204505 hasConceptScore W3168204505C2778754761 @default.
- W3168204505 hasConceptScore W3168204505C54355233 @default.
- W3168204505 hasConceptScore W3168204505C86803240 @default.
- W3168204505 hasConceptScore W3168204505C8891405 @default.
- W3168204505 hasConceptScore W3168204505C95444343 @default.
- W3168204505 hasIssue "S1" @default.
- W3168204505 hasLocation W31682045051 @default.
- W3168204505 hasOpenAccess W3168204505 @default.
- W3168204505 hasPrimaryLocation W31682045051 @default.
- W3168204505 hasRelatedWork W2056856060 @default.
- W3168204505 hasRelatedWork W2077117401 @default.
- W3168204505 hasRelatedWork W2113485094 @default.
- W3168204505 hasRelatedWork W2275022502 @default.
- W3168204505 hasRelatedWork W2382886602 @default.
- W3168204505 hasRelatedWork W2741813146 @default.
- W3168204505 hasRelatedWork W3146986594 @default.
- W3168204505 hasRelatedWork W3195291479 @default.
- W3168204505 hasRelatedWork W4310525957 @default.
- W3168204505 hasRelatedWork W4322501030 @default.
- W3168204505 hasVolume "24" @default.
- W3168204505 isParatext "false" @default.
- W3168204505 isRetracted "false" @default.
- W3168204505 magId "3168204505" @default.
- W3168204505 workType "article" @default.