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- W3168205842 abstract "A novel capillary-based microfluidic strategy to accelerate the process of small-molecule-compound screening by room-temperature X-ray crystallography using protein crystals is reported. The ultra-thin microfluidic devices are composed of a UV-curable polymer, patterned by cleanroom photolithography, and have nine capillary channels per chip. The chip was designed for ease of sample manipulation, sample stability and minimal X-ray background. 3D-printed frames and cassettes conforming to SBS standards are used to house the capillary chips, providing additional mechanical stability and compatibility with automated liquid- and sample-handling robotics. These devices enable an innovative in situ crystal-soaking screening workflow, akin to high-throughput compound screening, such that quantitative electron density maps sufficient to determine weak binding events are efficiently obtained. This work paves the way for adopting a room-temperature microfluidics-based sample delivery method at synchrotron sources to facilitate high-throughput protein-crystallography-based screening of compounds at high concentration with the aim of discovering novel binding events in an automated manner." @default.
- W3168205842 created "2021-06-22" @default.
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- W3168205842 date "2021-06-14" @default.
- W3168205842 modified "2023-10-15" @default.
- W3168205842 title "A capillary-based microfluidic device enables primary high-throughput room-temperature crystallographic screening" @default.
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- W3168205842 doi "https://doi.org/10.1107/s1600576721004155" @default.
- W3168205842 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8366422" @default.
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