Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168223604> ?p ?o ?g. }
- W3168223604 endingPage "1451" @default.
- W3168223604 startingPage "1438" @default.
- W3168223604 abstract "Mycobacterium ulcerans is the causal agent of Buruli ulcer, a chronic infectious disease and the third most common mycobacterial disease worldwide. Without early treatment, M. ulcerans provokes massive skin ulcers, caused by the mycolactone toxin, its main virulence factor. However, spontaneous healing may occur in Buruli ulcer patients several months or years after the disease onset. We have shown, in an original mouse model, that bacterial load remains high and viable in spontaneously healed tissues, with a switch of M. ulcerans to low levels of mycolactone production, adapting its strategy to survive in such a hostile environment. This original model offers the possibility to investigate the regulation of mycolactone production, by using an RNA-seq strategy to study bacterial adaptation during mouse infection. Pathway analysis and characterization of the tissue environment showed that the bacillus adapted to its new environment by modifying its metabolic activity and switching nutrient sources. Thus, M. ulcerans ensures its survival in healing tissues by reducing its secondary metabolism, leading to an inhibition of mycolactone synthesis. These findings shed new light on mycolactone regulation and pave the way for new therapeutic strategies." @default.
- W3168223604 created "2021-06-22" @default.
- W3168223604 creator A5006612133 @default.
- W3168223604 creator A5007964697 @default.
- W3168223604 creator A5046905007 @default.
- W3168223604 creator A5049972970 @default.
- W3168223604 creator A5053151249 @default.
- W3168223604 creator A5061550454 @default.
- W3168223604 creator A5063605857 @default.
- W3168223604 creator A5064937180 @default.
- W3168223604 creator A5077869553 @default.
- W3168223604 creator A5081731982 @default.
- W3168223604 creator A5083496550 @default.
- W3168223604 creator A5088644571 @default.
- W3168223604 date "2021-06-09" @default.
- W3168223604 modified "2023-10-13" @default.
- W3168223604 title "Transcriptional adaptation of <i>Mycobacterium ulcerans</i> in an original mouse model: New insights into the regulation of mycolactone" @default.
- W3168223604 cites W1520880969 @default.
- W3168223604 cites W1532224000 @default.
- W3168223604 cites W1565250952 @default.
- W3168223604 cites W1602455677 @default.
- W3168223604 cites W1757875555 @default.
- W3168223604 cites W1864461701 @default.
- W3168223604 cites W1973504122 @default.
- W3168223604 cites W1998518602 @default.
- W3168223604 cites W2004609943 @default.
- W3168223604 cites W2008563568 @default.
- W3168223604 cites W2014578355 @default.
- W3168223604 cites W2020009446 @default.
- W3168223604 cites W2033541022 @default.
- W3168223604 cites W2035459271 @default.
- W3168223604 cites W2047597508 @default.
- W3168223604 cites W2058991841 @default.
- W3168223604 cites W2061277860 @default.
- W3168223604 cites W2062795054 @default.
- W3168223604 cites W2063632665 @default.
- W3168223604 cites W2064458258 @default.
- W3168223604 cites W2077408214 @default.
- W3168223604 cites W2078663039 @default.
- W3168223604 cites W2089605616 @default.
- W3168223604 cites W2090902470 @default.
- W3168223604 cites W2107323176 @default.
- W3168223604 cites W2120574189 @default.
- W3168223604 cites W2124985265 @default.
- W3168223604 cites W2125112523 @default.
- W3168223604 cites W2127315505 @default.
- W3168223604 cites W2135269226 @default.
- W3168223604 cites W2138207763 @default.
- W3168223604 cites W2151892531 @default.
- W3168223604 cites W2165780813 @default.
- W3168223604 cites W2168957698 @default.
- W3168223604 cites W2179438025 @default.
- W3168223604 cites W2180987963 @default.
- W3168223604 cites W2187426740 @default.
- W3168223604 cites W2290579838 @default.
- W3168223604 cites W2293759222 @default.
- W3168223604 cites W2293942920 @default.
- W3168223604 cites W2562495944 @default.
- W3168223604 cites W2587971454 @default.
- W3168223604 cites W2595321450 @default.
- W3168223604 cites W2597862848 @default.
- W3168223604 cites W2614823621 @default.
- W3168223604 cites W2621384711 @default.
- W3168223604 cites W2738201557 @default.
- W3168223604 cites W2762985876 @default.
- W3168223604 cites W2781107938 @default.
- W3168223604 cites W2795204641 @default.
- W3168223604 cites W2800885808 @default.
- W3168223604 cites W2833016943 @default.
- W3168223604 cites W2965693496 @default.
- W3168223604 cites W3111493690 @default.
- W3168223604 cites W4241630870 @default.
- W3168223604 doi "https://doi.org/10.1080/21505594.2021.1929749" @default.
- W3168223604 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8204960" @default.
- W3168223604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34107844" @default.
- W3168223604 hasPublicationYear "2021" @default.
- W3168223604 type Work @default.
- W3168223604 sameAs 3168223604 @default.
- W3168223604 citedByCount "6" @default.
- W3168223604 countsByYear W31682236042022 @default.
- W3168223604 crossrefType "journal-article" @default.
- W3168223604 hasAuthorship W3168223604A5006612133 @default.
- W3168223604 hasAuthorship W3168223604A5007964697 @default.
- W3168223604 hasAuthorship W3168223604A5046905007 @default.
- W3168223604 hasAuthorship W3168223604A5049972970 @default.
- W3168223604 hasAuthorship W3168223604A5053151249 @default.
- W3168223604 hasAuthorship W3168223604A5061550454 @default.
- W3168223604 hasAuthorship W3168223604A5063605857 @default.
- W3168223604 hasAuthorship W3168223604A5064937180 @default.
- W3168223604 hasAuthorship W3168223604A5077869553 @default.
- W3168223604 hasAuthorship W3168223604A5081731982 @default.
- W3168223604 hasAuthorship W3168223604A5083496550 @default.
- W3168223604 hasAuthorship W3168223604A5088644571 @default.
- W3168223604 hasBestOaLocation W31682236041 @default.
- W3168223604 hasConcept C104317684 @default.
- W3168223604 hasConcept C139807058 @default.
- W3168223604 hasConcept C142724271 @default.
- W3168223604 hasConcept C169760540 @default.