Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168265280> ?p ?o ?g. }
- W3168265280 abstract "This paper addresses the application of multimodal nonlinear optical (MNLO) microscopy to clinical research within the context of label-free non-invasive molecular imaging. Here, a compact MNLO microscope based on a laser scanning microscope, a femtosecond laser, a time-correlated single-photon counting system, and a photonic crystal fiber are introduced for biomedical applications. By integrating two-photon fluorescence, two-photon fluorescence lifetime imaging, second-harmonic generation, and coherent anti-Stokes Raman scattering microscopy, the proposed scheme provides profound insights into the physicochemical properties related to 3D molecular orientation distribution, inter- and intra-molecular interactions, and disease progression in biological systems and organs. The high peak power and the low average intensity of near-infrared laser pulses allow for deep-penetration imaging without compromising sample vitality. Linking nonlinear optical phenomena with time/spectral/polarization-resolved imaging also makes it possible to obtain multidimensional information to address complex biomedical questions." @default.
- W3168265280 created "2021-06-22" @default.
- W3168265280 creator A5013846838 @default.
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- W3168265280 date "2021-06-01" @default.
- W3168265280 modified "2023-10-15" @default.
- W3168265280 title "Label-free multimodal nonlinear optical microscopy for biomedical applications" @default.
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