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• W3168276957 endingPage "2583" @default.
• W3168276957 startingPage "2583" @default.
• W3168276957 abstract "Observational studies have associated the increase in fibroblast growth factor (FGF) 23 levels, the main regulator of phosphate levels, with the onset of diabetes. These studies open the debate on the plausible existence of undescribed diabetogenic mechanisms derived from chronic supraphysiological levels of FGF23, a prevalent condition in chronic kidney disease (CKD) and end-stage renal disease (ESRD) patients. These maladaptive and diabetogenic responses to FGF23 may occur at different levels, including a direct effect on the pancreatic ß cells, and an indirect effect derived from the stimulation of the synthesis of pro-inflammatory factors. Both mechanisms could be mediated by the binding of FGF23 to noncanonical receptor complexes with the subsequent overactivation of signaling pathways that leads to harmful effects. The canonical binding of FGF23 to the receptor complex formed by the receptor FGFR1c and the coreceptor αKlotho activates Ras/MAPK/ERK signaling. However, supraphysiological concentrations of FGF23 favor non-αKlotho-dependent binding of this molecule to other FGFRs, which could generate an undesired overactivation of the PLCγ/CN/NFAT pathway, as observed in cardiomyocytes and hepatocytes. Moreover, the decrease in αKlotho expression may constitute a contributing factor to the appearance of these effects by promoting the nonspecific activation of the PLCγ/CN/NFAT to the detriment of the αKlotho-dependent Ras/MAPK/ERK pathway. The description of these mechanisms would allow the development of new therapeutic targets susceptible to be modified by dietary changes or by pharmacological intervention." @default.
• W3168276957 created "2021-06-22" @default.
• W3168276957 creator A5030615962 @default.
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• W3168276957 date "2021-06-11" @default.
• W3168276957 modified "2023-10-11" @default.
• W3168276957 title "Pathophysiological Implications of Imbalances in Fibroblast Growth Factor 23 in the Development of Diabetes" @default.
• W3168276957 cites W1504986323 @default.
• W3168276957 cites W1569944510 @default.
• W3168276957 cites W1952338989 @default.
• W3168276957 cites W1963306946 @default.
• W3168276957 cites W1965113966 @default.
• W3168276957 cites W1965358479 @default.
• W3168276957 cites W1969615213 @default.
• W3168276957 cites W1972662184 @default.
• W3168276957 cites W1978180139 @default.
• W3168276957 cites W1980470796 @default.
• W3168276957 cites W1985595661 @default.
• W3168276957 cites W1992510938 @default.
• W3168276957 cites W1998221258 @default.
• W3168276957 cites W2000665430 @default.
• W3168276957 cites W2003432611 @default.
• W3168276957 cites W2003905949 @default.
• W3168276957 cites W2006777459 @default.
• W3168276957 cites W2008282188 @default.
• W3168276957 cites W2010388623 @default.
• W3168276957 cites W2012209979 @default.
• W3168276957 cites W2014663082 @default.
• W3168276957 cites W2015668150 @default.
• W3168276957 cites W2018135697 @default.
• W3168276957 cites W2019078181 @default.
• W3168276957 cites W2021852822 @default.
• W3168276957 cites W2023869058 @default.
• W3168276957 cites W2025170983 @default.
• W3168276957 cites W2031941775 @default.
• W3168276957 cites W2037498463 @default.
• W3168276957 cites W2045559539 @default.
• W3168276957 cites W2054195724 @default.
• W3168276957 cites W2056059734 @default.
• W3168276957 cites W2058721308 @default.
• W3168276957 cites W2063970883 @default.
• W3168276957 cites W2065426711 @default.
• W3168276957 cites W2069321199 @default.
• W3168276957 cites W2075500765 @default.
• W3168276957 cites W2086855587 @default.
• W3168276957 cites W2087096258 @default.
• W3168276957 cites W2089363189 @default.
• W3168276957 cites W2091948921 @default.
• W3168276957 cites W2095511505 @default.
• W3168276957 cites W2099196302 @default.
• W3168276957 cites W2100168006 @default.
• W3168276957 cites W2105125729 @default.
• W3168276957 cites W2105398326 @default.
• W3168276957 cites W2106986971 @default.
• W3168276957 cites W2107094803 @default.
• W3168276957 cites W2107420262 @default.
• W3168276957 cites W2107726672 @default.
• W3168276957 cites W2108876913 @default.
• W3168276957 cites W2109228279 @default.
• W3168276957 cites W2111614075 @default.
• W3168276957 cites W2111653877 @default.
• W3168276957 cites W2114360920 @default.
• W3168276957 cites W2114650931 @default.
• W3168276957 cites W2119707586 @default.
• W3168276957 cites W2119911529 @default.
• W3168276957 cites W2120672697 @default.
• W3168276957 cites W2121435915 @default.
• W3168276957 cites W2122892477 @default.
• W3168276957 cites W2123082215 @default.
• W3168276957 cites W2126660234 @default.
• W3168276957 cites W2130105820 @default.
• W3168276957 cites W2130585857 @default.
• W3168276957 cites W2133643436 @default.
• W3168276957 cites W2137720344 @default.
• W3168276957 cites W2141233355 @default.
• W3168276957 cites W2141298701 @default.
• W3168276957 cites W2143729965 @default.
• W3168276957 cites W2159323221 @default.
• W3168276957 cites W2164683872 @default.
• W3168276957 cites W2170351820 @default.
• W3168276957 cites W2245274613 @default.
• W3168276957 cites W2274689835 @default.
• W3168276957 cites W2276328695 @default.
• W3168276957 cites W2281324551 @default.
• W3168276957 cites W2324343996 @default.
• W3168276957 cites W2333388731 @default.
• W3168276957 cites W2411826498 @default.
• W3168276957 cites W2477224043 @default.
• W3168276957 cites W2498525015 @default.
• W3168276957 cites W2529168105 @default.
• W3168276957 cites W2553963191 @default.
• W3168276957 cites W2576527809 @default.

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