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- W3168303790 abstract "Advanced non-small cell lung cancer (NSCLC) has faced a therapeutic revolution with the advent of tyrosine kinase inhibitors (TKIs) and immune checkpoints inhibitors (ICIs) approved for first and subsequent therapies. CIMAvax-EGF is a chemical conjugate between human-recombinant EGF and P64, a recombinant protein from Neisseria meningitides, which induces neutralizing antibodies against EGF. In the last 15 years, it has been extensively evaluated in advanced NSCLC patients. CIMAvax-EGF is safe, even after extended use, and able to keep EGF serum concentration below detectable levels. In a randomized phase III study, CIMAvax-EGF increased median overall survival of advanced NSCLC patients with at least stable disease after front-line chemotherapy. Patients bearing squamous-cell or adenocarcinomas and serum EGF concentration above 870 pg/ml had better survival compared to control patients treated with best supportive care as maintenance, confirming tumors' sensitivity to the EGF depletion. This manuscript reviews the state-of-the-art NSCLC therapy and proposes the most promising scenarios for evaluating CIMAvax-EGF, particularly in combination with TKIs or ICIs. We hypothesize that the optimal combination of CIMAvax-EGF with established therapies can further contribute to transform advanced cancer into a manageable chronic disease, compatible with years of good quality of life." @default.
- W3168303790 created "2021-06-22" @default.
- W3168303790 creator A5011498992 @default.
- W3168303790 creator A5025646273 @default.
- W3168303790 creator A5049794869 @default.
- W3168303790 creator A5084446167 @default.
- W3168303790 creator A5085015077 @default.
- W3168303790 date "2021-06-15" @default.
- W3168303790 modified "2023-10-17" @default.
- W3168303790 title "The Position of EGF Deprivation in the Management of Advanced Non-Small Cell Lung Cancer" @default.
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