FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168355141> ?p ?o ?g. }

• W3168355141 endingPage "100932" @default.
• W3168355141 startingPage "100932" @default.
• W3168355141 abstract "Cytochrome P450 3A4 ( CYP3A4 ), the main drug-metabolizing enzyme in the liver, has a functional SNP in intron six named CYP3A4 ⁎ 22 . Given the CYP3A4 ⁎ 22 polymorphism effect on the reduced CYP3A4 mRNA/protein expression, this study aimed to evaluate the prevalence of CYP3A4 ⁎ 22 polymorphism in Iranian patients with stroke compared to the control group. A total of 175 patients with stroke and 236 control age-sex matched ones have been examined for CYP3A4 ⁎ 22 polymorphism by Tetra ARMS-PCR methods. The results were confirmed by the PCR-RFLP technique and the sequencing of DNA. This study is the first report of CYP3A4 ⁎ 22 polymorphism from Iran. The frequency of the CYP3A4 ⁎ 22 wild-type (GG genotype) and heterozygous genotypes (GA genotype) was 93.1% and 6.9% in patients, and 92.8% and 7.2% in the controls, respectively. None of the participants was the recessive model for this polymorphism. There were no statistical differences between the patient and control groups ( p > 0.05). Also, the GA genotype was not associated with increased risk of stroke compared with the GG genotype (OR = 0.95, 95% CI: 0.44–2.04, P = 0.892). Since CYP3A4 ⁎ 22 polymorphism may result in reduced CYP3A4 activity in vivo, due to the large number of drugs that are CYP3A4 substrates, individuals with this polymorphism may experience unusual drug effects. To clarify these impacts, further investigations are, therefore, needed to be done." @default.
• W3168355141 created "2021-06-22" @default.
• W3168355141 creator A5020507751 @default.
• W3168355141 creator A5026351149 @default.
• W3168355141 creator A5026818585 @default.
• W3168355141 creator A5047193276 @default.
• W3168355141 creator A5078412581 @default.
• W3168355141 creator A5080408998 @default.
• W3168355141 date "2021-09-01" @default.
• W3168355141 modified "2023-10-17" @default.
• W3168355141 title "CYP3A4⁎22 gene polymorphism and risk of ischemic stroke in south Iran population: A case control study" @default.
• W3168355141 cites W2017582897 @default.
• W3168355141 cites W2018784274 @default.
• W3168355141 cites W2022800946 @default.
• W3168355141 cites W2031155689 @default.
• W3168355141 cites W2054323958 @default.
• W3168355141 cites W2054532619 @default.
• W3168355141 cites W2086486611 @default.
• W3168355141 cites W2112667001 @default.
• W3168355141 cites W2116232595 @default.
• W3168355141 cites W2117641691 @default.
• W3168355141 cites W2131319167 @default.
• W3168355141 cites W2132236118 @default.
• W3168355141 cites W2135057359 @default.
• W3168355141 cites W2135711647 @default.
• W3168355141 cites W2137151087 @default.
• W3168355141 cites W2142436506 @default.
• W3168355141 cites W2151586219 @default.
• W3168355141 cites W2155477484 @default.
• W3168355141 cites W2335837408 @default.
• W3168355141 cites W2580764146 @default.
• W3168355141 cites W2605348885 @default.
• W3168355141 cites W2771173033 @default.
• W3168355141 cites W2944722866 @default.
• W3168355141 cites W3019065741 @default.
• W3168355141 cites W3033613295 @default.
• W3168355141 cites W3046561378 @default.
• W3168355141 cites W3075933067 @default.
• W3168355141 doi "https://doi.org/10.1016/j.mgene.2021.100932" @default.
• W3168355141 hasPublicationYear "2021" @default.
• W3168355141 type Work @default.
• W3168355141 sameAs 3168355141 @default.
• W3168355141 citedByCount "1" @default.
• W3168355141 countsByYear W31683551412022 @default.
• W3168355141 crossrefType "journal-article" @default.
• W3168355141 hasAuthorship W3168355141A5020507751 @default.
• W3168355141 hasAuthorship W3168355141A5026351149 @default.
• W3168355141 hasAuthorship W3168355141A5026818585 @default.
• W3168355141 hasAuthorship W3168355141A5047193276 @default.
• W3168355141 hasAuthorship W3168355141A5078412581 @default.
• W3168355141 hasAuthorship W3168355141A5080408998 @default.
• W3168355141 hasConcept C104317684 @default.
• W3168355141 hasConcept C109650736 @default.
• W3168355141 hasConcept C126322002 @default.
• W3168355141 hasConcept C135763542 @default.
• W3168355141 hasConcept C139275648 @default.
• W3168355141 hasConcept C146304588 @default.
• W3168355141 hasConcept C149737253 @default.
• W3168355141 hasConcept C153209595 @default.
• W3168355141 hasConcept C168007829 @default.
• W3168355141 hasConcept C2908647359 @default.
• W3168355141 hasConcept C526171541 @default.
• W3168355141 hasConcept C54355233 @default.
• W3168355141 hasConcept C62231903 @default.
• W3168355141 hasConcept C71924100 @default.
• W3168355141 hasConcept C76252995 @default.
• W3168355141 hasConcept C86803240 @default.
• W3168355141 hasConcept C90924648 @default.
• W3168355141 hasConcept C99454951 @default.
• W3168355141 hasConceptScore W3168355141C104317684 @default.
• W3168355141 hasConceptScore W3168355141C109650736 @default.
• W3168355141 hasConceptScore W3168355141C126322002 @default.
• W3168355141 hasConceptScore W3168355141C135763542 @default.
• W3168355141 hasConceptScore W3168355141C139275648 @default.
• W3168355141 hasConceptScore W3168355141C146304588 @default.
• W3168355141 hasConceptScore W3168355141C149737253 @default.
• W3168355141 hasConceptScore W3168355141C153209595 @default.
• W3168355141 hasConceptScore W3168355141C168007829 @default.
• W3168355141 hasConceptScore W3168355141C2908647359 @default.
• W3168355141 hasConceptScore W3168355141C526171541 @default.
• W3168355141 hasConceptScore W3168355141C54355233 @default.
• W3168355141 hasConceptScore W3168355141C62231903 @default.
• W3168355141 hasConceptScore W3168355141C71924100 @default.
• W3168355141 hasConceptScore W3168355141C76252995 @default.
• W3168355141 hasConceptScore W3168355141C86803240 @default.
• W3168355141 hasConceptScore W3168355141C90924648 @default.
• W3168355141 hasConceptScore W3168355141C99454951 @default.
• W3168355141 hasFunder F4320322545 @default.
• W3168355141 hasLocation W31683551411 @default.
• W3168355141 hasOpenAccess W3168355141 @default.
• W3168355141 hasPrimaryLocation W31683551411 @default.
• W3168355141 hasRelatedWork W1853889937 @default.
• W3168355141 hasRelatedWork W2347978952 @default.
• W3168355141 hasRelatedWork W2359440310 @default.
• W3168355141 hasRelatedWork W2367937357 @default.
• W3168355141 hasRelatedWork W2376945250 @default.
• W3168355141 hasRelatedWork W2381084781 @default.
• W3168355141 hasRelatedWork W2383289368 @default.

• next