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- W3168375180 endingPage "20.2021" @default.
- W3168375180 startingPage "ENEURO.0263" @default.
- W3168375180 abstract "Abstract Intrauterine growth restriction (IUGR) and oxygen exposure in isolation and combination adversely affect the developing brain, putting infants at risk for neurodevelopmental disability including cerebral palsy (CP). Rodent models of IUGR and postnatal hyperoxia have demonstrated oligodendroglial (OL) injury with subsequent white matter injury (WMI) and motor dysfunction. Here, we investigate transcriptomic dysregulation in IUGR with and without hyperoxia exposure to account for the abnormal brain structure and function previously documented. We performed RNA sequencing and analysis using a mouse model of IUGR and found that IUGR, hyperoxia, and the combination of IUGR with hyperoxia (IUGR/hyperoxia) produced distinct changes in gene expression. IUGR in isolation demonstrated the fewest differentially expressed genes (DEGs) compared with control. In contrast, we detected several gene alterations in IUGR/hyperoxia; genes involved in myelination were strikingly downregulated. We also identified changes to specific regulators including TCF7L2, BDNF, SOX2, and DGCR8, through ingenuity pathway analysis (IPA), that may contribute to impaired myelination in IUGR/hyperoxia. Our findings show that IUGR with hyperoxia induces unique transcriptional changes in the developing brain. These indicate mechanisms for increased risk for WMI in IUGR infants exposed to oxygen and suggest potential therapeutic targets to improve motor outcomes." @default.
- W3168375180 created "2021-06-22" @default.
- W3168375180 creator A5002035834 @default.
- W3168375180 creator A5004716484 @default.
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- W3168375180 creator A5053500031 @default.
- W3168375180 creator A5071431410 @default.
- W3168375180 creator A5075286832 @default.
- W3168375180 date "2021-06-07" @default.
- W3168375180 modified "2023-10-16" @default.
- W3168375180 title "Intrauterine Growth Restriction Followed by Oxygen Support Uniquely Interferes with Genetic Regulators of Myelination" @default.
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