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• W3168419717 abstract "Abstract Background Endoscopic remission is associated with better outcomes in ulcerative colitis (UC). However, colonoscopy (CS) is invasive and poorly tolerated by patients. Recently, we developed and externally validated non-invasive ultrasonography based criteria [Milan ultrasound criteria (MUC)] to assess and grade endoscopic activity in UC. We also confirmed that a MUC score &gt; 6.2 is a valid cut-off to discriminate endoscopic activity, defined by a Mayo endoscopic subscore &gt; 2. Aim of this study was to assess the predictive role of MUC on disease course in a prospective cohort of UC patients. Methods UC consecutive patients were followed for at least 12 months after performing baseline bowel US. UC-related outcomes, including need of treatment escalation (defined as the need of corticosteroids or change/optimization of immunosuppressants), hospitalization and surgery, were assessed at 1 year by logistic regression analysis, and were analyzed after long term follow-up (5 years) using Kaplan-Meier survival analysis. Fig. 1A and 1B. Kaplan–Meier curves for the cumulative probability of hospitalization and surgery in patients with Milan ultrasound criteria (MUC) &lt; 6.2 (solid line) or MUC &gt; 6.2 (dotted line). (p= 0.046; p= 0.023; respectively). Fig. 1C and 1D. Kaplan–Meier curves for the cumulative probability of hospitalization and surgery in patients with Mayo endoscopic subscore 0–1 (solid line) or 2–3 (dotted line). (p= 0.035; p= 0.071; respectively). Results 87 UC consecutive patients were included in the study, 31 (36%) were in endoscopic remission (Mayo endoscopic subscore 0–1) and 56 (64%) in endoscopic activity (Mayo endoscopic subscore 2–3). MUC and Mayo endoscopic subscore significantly correlated at baseline (Spearman’s rank correlations [rho]= 0.642; 95% confidence interval (CI) 0.499 to 0.751; p &lt; 0.001). The multivariable analysis identified as independent predictors of need of treatment escalation throughout the 12-month period as being: MUC &gt; 6.2 (OR: 5.95, 95% CI: 1.32–26.76, p &lt; 0.020) and a partial Mayo score (PMS) &gt; 2 (OR: 26.88, 95% CI: 5.01–144.07, p &lt; 0.001). Kaplan-Meier survival analysis of long-term follow up demonstrated a lower cumulative probability of need for surgery and hospitalization in patients with MUC &lt; 6.2 compared to MUC &gt; 6.2 (Fig. 1A and 1B), as well as in patients with a Mayo endoscopic subscore of &lt; 1 compared to Mayo endoscopic subscore of 2–3 (Fig. 1C and 1D). Conclusion MUC is a novel non invasive tool that predicts the course of UC in the short and long term follow-up." @default.
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• W3168419717 date "2021-05-01" @default.
• W3168419717 modified "2023-10-16" @default.
• W3168419717 title "OP21 Predictive value of Milan Ultrasound Criteria in Ulcerative Colitis: A prospective observational cohort study" @default.
• W3168419717 doi "https://doi.org/10.1093/ecco-jcc/jjab075.020" @default.
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