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- W3168431619 endingPage "688" @default.
- W3168431619 startingPage "653" @default.
- W3168431619 abstract "A number of new developments in molecular biology, metabolic engineering, chemical analytics and DNA sequencing have led to renewed interest in novel bioactive natural products from actinomycetes. The chemical diversity of the bioactive natural products is immense and also reflected in the complexity of the biosynthetic pathways involved in their biosynthesis. Due to their immense potential to produce bioactive natural products, most metabolic engineering work on filamentous actinomycetes focuses on the identification of novel compounds or the production optimization of specific target molecules. Cloning and heterologous expression of biosynthetic gene clusters (BGCs) is a widely used approach as many actinomycetes, especially outside the Streptomyces genus, are difficult or even impossible to genetically manipulate. The expression of BGCs encoding natural products is a complex process highly regulated through the interactions of both pleiotropic and pathway-specific regulators. Genome-scale metabolic models of different actinomycetes have assisted experimental efforts to engineer strains and boost production of target compounds." @default.
- W3168431619 created "2021-06-22" @default.
- W3168431619 creator A5012284858 @default.
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- W3168431619 date "2021-06-04" @default.
- W3168431619 modified "2023-09-27" @default.
- W3168431619 title "Metabolic Engineering of Filamentous Actinomycetes" @default.
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