FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168448920> ?p ?o ?g. }

• W3168448920 abstract "Ovarian cancer (OV) is the fifth most common type of cancer affecting women worldwide. Long non‑coding RNAs (lncRNAs) serve essential roles in the progression of OV. As such, the present study aimed to investigate the specific role of HAGLR opposite strand lncRNA (HAGLROS) in OV and the underlying mechanism of action through which HAGLROS exerts its effects on OV cells. In the present study, the expression of HAGLROS in several OV cell lines was first detected using reverse transcription‑quantitative PCR. HAGLROS was then silenced to evaluate cell viability, proliferation and apoptosis, which were determined using Cell Counting Kit‑8, colony formation and TUNEL assays, respectively. Additionally, immunofluorescence staining and western blotting were used to confirm the expression profile of proliferation‑ and apoptosis‑related proteins. Moreover, a dual luciferase reporter assay was used to verify the potential interactions between HAGLROS and microRNA (miR)‑26b‑5p. Subsequently, rescue assays were performed to investigate the effects of HAGLROS and miR‑26b‑5p on OV progression. The results indicated that HAGLROS was highly expressed in OV cells. Interference of HAGLROS led to a decrease in the proliferation, but an increase in the apoptosis of OV cells, accompanied by downregulated expression levels of Ki67 and Bcl‑2, and upregulated expression levels of Bax and cleaved caspase‑3. Further study revealed that HAGLROS acted as a sponge for miR‑26b‑5p and positively regulated its expression. miR‑26b‑5p inhibitor transfection partially reversed the effects of HAGLROS knockdown on the proliferation and apoptosis of OV cells. In conclusion, the results of the present study suggested that interference of HAGLROS suppressed the proliferation and promoted the apoptosis of OV cells through regulating miR‑26b‑5p, indicating that HAGLROS may be a promising biomarker in OV diagnosis and treatment." @default.
• W3168448920 created "2021-06-22" @default.
• W3168448920 creator A5051655206 @default.
• W3168448920 creator A5066392725 @default.
• W3168448920 date "2021-06-15" @default.
• W3168448920 modified "2023-10-17" @default.
• W3168448920 title "Interference of long non‑coding RNA HAGLROS inhibits the proliferation and promotes the apoptosis of ovarian cancer cells by targeting miR‑26b‑5p" @default.
• W3168448920 cites W1487554336 @default.
• W3168448920 cites W1966932597 @default.
• W3168448920 cites W2067625941 @default.
• W3168448920 cites W2075086352 @default.
• W3168448920 cites W2107277218 @default.
• W3168448920 cites W2136222002 @default.
• W3168448920 cites W2219177006 @default.
• W3168448920 cites W2223740898 @default.
• W3168448920 cites W2279085311 @default.
• W3168448920 cites W2293426979 @default.
• W3168448920 cites W2784130733 @default.
• W3168448920 cites W2789405549 @default.
• W3168448920 cites W2802418606 @default.
• W3168448920 cites W2883223808 @default.
• W3168448920 cites W2893787701 @default.
• W3168448920 cites W2901999217 @default.
• W3168448920 cites W2917837889 @default.
• W3168448920 cites W2918459787 @default.
• W3168448920 cites W2944745257 @default.
• W3168448920 cites W2950927220 @default.
• W3168448920 cites W2972455194 @default.
• W3168448920 cites W2995850814 @default.
• W3168448920 cites W3008465931 @default.
• W3168448920 cites W3011399478 @default.
• W3168448920 cites W3029638879 @default.
• W3168448920 cites W3084158254 @default.
• W3168448920 cites W3085942608 @default.
• W3168448920 cites W3088465295 @default.
• W3168448920 cites W3095580630 @default.
• W3168448920 cites W3100930143 @default.
• W3168448920 cites W3101904807 @default.
• W3168448920 cites W3025857719 @default.
• W3168448920 doi "https://doi.org/10.3892/etm.2021.10311" @default.
• W3168448920 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8237406" @default.
• W3168448920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34194557" @default.
• W3168448920 hasPublicationYear "2021" @default.
• W3168448920 type Work @default.
• W3168448920 sameAs 3168448920 @default.
• W3168448920 citedByCount "8" @default.
• W3168448920 countsByYear W31684489202021 @default.
• W3168448920 countsByYear W31684489202022 @default.
• W3168448920 countsByYear W31684489202023 @default.
• W3168448920 crossrefType "journal-article" @default.
• W3168448920 hasAuthorship W3168448920A5051655206 @default.
• W3168448920 hasAuthorship W3168448920A5066392725 @default.
• W3168448920 hasBestOaLocation W31684489201 @default.
• W3168448920 hasConcept C104317684 @default.
• W3168448920 hasConcept C145059251 @default.
• W3168448920 hasConcept C1491633281 @default.
• W3168448920 hasConcept C153911025 @default.
• W3168448920 hasConcept C166703698 @default.
• W3168448920 hasConcept C173396325 @default.
• W3168448920 hasConcept C190283241 @default.
• W3168448920 hasConcept C2781018059 @default.
• W3168448920 hasConcept C29537977 @default.
• W3168448920 hasConcept C502942594 @default.
• W3168448920 hasConcept C54009773 @default.
• W3168448920 hasConcept C54355233 @default.
• W3168448920 hasConcept C62112901 @default.
• W3168448920 hasConcept C67705224 @default.
• W3168448920 hasConcept C81885089 @default.
• W3168448920 hasConcept C86803240 @default.
• W3168448920 hasConcept C95444343 @default.
• W3168448920 hasConceptScore W3168448920C104317684 @default.
• W3168448920 hasConceptScore W3168448920C145059251 @default.
• W3168448920 hasConceptScore W3168448920C1491633281 @default.
• W3168448920 hasConceptScore W3168448920C153911025 @default.
• W3168448920 hasConceptScore W3168448920C166703698 @default.
• W3168448920 hasConceptScore W3168448920C173396325 @default.
• W3168448920 hasConceptScore W3168448920C190283241 @default.
• W3168448920 hasConceptScore W3168448920C2781018059 @default.
• W3168448920 hasConceptScore W3168448920C29537977 @default.
• W3168448920 hasConceptScore W3168448920C502942594 @default.
• W3168448920 hasConceptScore W3168448920C54009773 @default.
• W3168448920 hasConceptScore W3168448920C54355233 @default.
• W3168448920 hasConceptScore W3168448920C62112901 @default.
• W3168448920 hasConceptScore W3168448920C67705224 @default.
• W3168448920 hasConceptScore W3168448920C81885089 @default.
• W3168448920 hasConceptScore W3168448920C86803240 @default.
• W3168448920 hasConceptScore W3168448920C95444343 @default.
• W3168448920 hasIssue "2" @default.
• W3168448920 hasLocation W31684489201 @default.
• W3168448920 hasLocation W31684489202 @default.
• W3168448920 hasOpenAccess W3168448920 @default.
• W3168448920 hasPrimaryLocation W31684489201 @default.
• W3168448920 hasRelatedWork W1518035471 @default.
• W3168448920 hasRelatedWork W1940124135 @default.
• W3168448920 hasRelatedWork W2159406762 @default.
• W3168448920 hasRelatedWork W2377185255 @default.
• W3168448920 hasRelatedWork W2386797884 @default.
• W3168448920 hasRelatedWork W2529723636 @default.
• W3168448920 hasRelatedWork W2544787839 @default.
• W3168448920 hasRelatedWork W2562103693 @default.

• next