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• W3168514486 abstract "Air pollution exposure has been linked with diminished fertility. Identifying the metabolic changes induced by periconception air pollution exposure among women could enhance our understanding of the potential biological pathways underlying air pollution's reproductive toxicity.To identify serum metabolites associated with periconception air pollution exposure and evaluate the extent to which these metabolites mediate the association between air pollution and live birth.We included 200 women undergoing a fresh assisted reproductive technology (ART) cycle at Massachusetts General Hospital Fertility Center (2005-2015). A serum sample was collected during stimulation, and untargeted metabolic profiling was conducted using liquid chromatography with ultra-high-resolution mass spectrometry. Exposure to nitrogen dioxide (NO2), ozone (O3), fine particulate matter <2.5 µm (PM2.5), and black carbon (BC) was estimated using validated spatiotemporal models. Multivariable linear regression models were used to evaluate the associations between the air pollutants, live birth, and metabolic feature intensities. A meet in the middle approach was used to identify overlapping features and metabolic pathways.From the C18 and HILIC chromatography columns, 10,803 and 12,968 metabolic features were extracted. There were 190 metabolic features and 18 pathways that were significantly associated with both air pollution and live birth (P < 0.05) across chromatography columns. Eight features were confirmed metabolites implicated in amino acid and nutrient metabolism with downstream effects on oxidative stress and inflammation. Six confirmed metabolites fell into two intuitive clusters - antioxidants and oxidants- which could potentially mediate some of the association between air pollution and lower odds of live birth. Tryptophan and vitamin B3 metabolism were common pathways linking air pollution exposure to decreased probability of live birth.Higher periconception air pollution exposure was associated with metabolites and biologic pathways involved in inflammation and oxidative stress that may mediate the observed associations with lower probability of live birth following ART." @default.
• W3168514486 created "2021-06-22" @default.
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• W3168514486 date "2021-10-01" @default.
• W3168514486 modified "2023-10-12" @default.
• W3168514486 title "Periconception air pollution, metabolomic biomarkers, and fertility among women undergoing assisted reproduction" @default.
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• W3168514486 doi "https://doi.org/10.1016/j.envint.2021.106666" @default.
• W3168514486 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8292230" @default.
• W3168514486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34116378" @default.
• W3168514486 hasPublicationYear "2021" @default.
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