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- W3168514662 abstract "Length control is a fundamental requirement for molecular architecture. Even small wall-less bacteria have specially developed macro-molecular structures to support their survival. Mycoplasma pneumoniae , a human pathogen, forms a polar extension called an attachment organelle, which mediates cell division, cytadherence, and cell movement at host cell surface. This characteristic ultrastructure has a constant size of 250–300 nm, but its design principle remains unclear. In this study, we constructed several mutants by genetic manipulation to increase or decrease coiled-coil regions of HMW2, a major component protein of 200 kDa aligned in parallel along the cell axis. HMW2-engineered mutants produced both long and short attachment organelles, which we quantified by transmission electron microscopy and fluorescent microscopy with nano-meter precision. This simple design of HMW2 acting as a molecular ruler for the attachment organelle should provide an insight into bacterial cellular organization and its function for their parasitic lifestyles." @default.
- W3168514662 created "2021-06-22" @default.
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- W3168514662 date "2021-06-10" @default.
- W3168514662 modified "2023-10-18" @default.
- W3168514662 title "Molecular ruler of the attachment organelle in Mycoplasma pneumoniae" @default.
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- W3168514662 doi "https://doi.org/10.1371/journal.ppat.1009621" @default.
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