Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168555770> ?p ?o ?g. }
- W3168555770 endingPage "701" @default.
- W3168555770 startingPage "685" @default.
- W3168555770 abstract "Activation of various isoforms of NADPH oxidase contributes to the pathogenesis of asthma at multiple levels: promoting hypercontractility, hypertrophy, and proliferation of airway smooth muscle; enabling lung influx of eosinophils via VCAM-1; and mediating allergen-induced mast cell activation. Free bilirubin, which functions physiologically within cells as a feedback inhibitor of NADPH oxidase complexes, has been shown to have a favorable impact on each of these phases of asthma pathogenesis. The spirulina chromophore phycocyanobilin (PhyCB), a homolog of bilirubin's precursor biliverdin, can mimic the inhibitory impact of biliverdin/bilirubin on NADPH oxidase activity, and spirulina's versatile and profound anti-inflammatory activity in rodent studies suggests that PhyCB may have potential as a clinical inhibitor of NADPH oxidase. Hence, spirulina or PhyCB-enriched spirulina extracts merit clinical evaluation in asthma. Promoting biosynthesis of glutathione and increasing the expression and activity of various antioxidant enzymes - as by supplementing with N-acetylcysteine, Phase 2 inducers (eg, lipoic acid), selenium, and zinc - may also blunt the contribution of oxidative stress to asthma pathogenesis. Nitric oxide (NO) and hydrogen sulfide (H2S) work in various ways to oppose pathogenic mechanisms in asthma; supplemental citrulline and high-dose folate may aid NO synthesis, high-dose biotin may mimic and possibly potentiate NO's activating impact on soluble guanylate cyclase, and NAC and taurine may boost H2S synthesis. The amino acid glycine has a hyperpolarizing effect on airway smooth muscle that is bronchodilatory. Insuring optimal intracellular levels of magnesium may modestly blunt the stimulatory impact of intracellular free calcium on bronchoconstriction. Nutraceutical regimens or functional foods incorporating at least several of these agents may have utility as nutraceutical adjuvants to standard clinical management of asthma." @default.
- W3168555770 created "2021-06-22" @default.
- W3168555770 creator A5005136857 @default.
- W3168555770 creator A5062304309 @default.
- W3168555770 creator A5064469464 @default.
- W3168555770 date "2021-06-01" @default.
- W3168555770 modified "2023-10-12" @default.
- W3168555770 title "Review – Nutraceuticals Can Target Asthmatic Bronchoconstriction: NADPH Oxidase-Dependent Oxidative Stress, RhoA and Calcium Dynamics" @default.
- W3168555770 cites W1070477317 @default.
- W3168555770 cites W1497515855 @default.
- W3168555770 cites W1553174726 @default.
- W3168555770 cites W1568617917 @default.
- W3168555770 cites W1592164162 @default.
- W3168555770 cites W1618146939 @default.
- W3168555770 cites W1822196508 @default.
- W3168555770 cites W1893689834 @default.
- W3168555770 cites W1936249832 @default.
- W3168555770 cites W1953208927 @default.
- W3168555770 cites W1964641978 @default.
- W3168555770 cites W1965137017 @default.
- W3168555770 cites W1965710900 @default.
- W3168555770 cites W1967536482 @default.
- W3168555770 cites W1967552970 @default.
- W3168555770 cites W1968750053 @default.
- W3168555770 cites W1969833190 @default.
- W3168555770 cites W1970245313 @default.
- W3168555770 cites W1975124499 @default.
- W3168555770 cites W1976193635 @default.
- W3168555770 cites W1976560720 @default.
- W3168555770 cites W1978012368 @default.
- W3168555770 cites W1980731080 @default.
- W3168555770 cites W1983016535 @default.
- W3168555770 cites W1984628433 @default.
- W3168555770 cites W1985145950 @default.
- W3168555770 cites W1985440102 @default.
- W3168555770 cites W1987637787 @default.
- W3168555770 cites W1990470477 @default.
- W3168555770 cites W1991142359 @default.
- W3168555770 cites W1991366770 @default.
- W3168555770 cites W1991628500 @default.
- W3168555770 cites W1991764806 @default.
- W3168555770 cites W1994008915 @default.
- W3168555770 cites W1996060659 @default.
- W3168555770 cites W1996971959 @default.
- W3168555770 cites W2002178803 @default.
- W3168555770 cites W2003305424 @default.
- W3168555770 cites W2004646866 @default.
- W3168555770 cites W2007936423 @default.
- W3168555770 cites W2008555302 @default.
- W3168555770 cites W2008960727 @default.
- W3168555770 cites W2012778341 @default.
- W3168555770 cites W2013735825 @default.
- W3168555770 cites W2014633444 @default.
- W3168555770 cites W2015745061 @default.
- W3168555770 cites W2017501501 @default.
- W3168555770 cites W2018572283 @default.
- W3168555770 cites W2021883819 @default.
- W3168555770 cites W2022773559 @default.
- W3168555770 cites W2025210666 @default.
- W3168555770 cites W2027245158 @default.
- W3168555770 cites W2028935738 @default.
- W3168555770 cites W2030576423 @default.
- W3168555770 cites W2031611610 @default.
- W3168555770 cites W2032374099 @default.
- W3168555770 cites W2032473534 @default.
- W3168555770 cites W2034446363 @default.
- W3168555770 cites W2041325182 @default.
- W3168555770 cites W2041456315 @default.
- W3168555770 cites W2043239658 @default.
- W3168555770 cites W2043656946 @default.
- W3168555770 cites W2043658797 @default.
- W3168555770 cites W2045151025 @default.
- W3168555770 cites W2050761331 @default.
- W3168555770 cites W2051691177 @default.
- W3168555770 cites W2053354220 @default.
- W3168555770 cites W2053419378 @default.
- W3168555770 cites W2056973414 @default.
- W3168555770 cites W2058826415 @default.
- W3168555770 cites W2062145087 @default.
- W3168555770 cites W2062244338 @default.
- W3168555770 cites W2065463296 @default.
- W3168555770 cites W2065572304 @default.
- W3168555770 cites W2069709554 @default.
- W3168555770 cites W2071318902 @default.
- W3168555770 cites W2072562539 @default.
- W3168555770 cites W2075282777 @default.
- W3168555770 cites W2075515103 @default.
- W3168555770 cites W2077941478 @default.
- W3168555770 cites W2078974726 @default.
- W3168555770 cites W2083165373 @default.
- W3168555770 cites W2083441169 @default.
- W3168555770 cites W2083643862 @default.
- W3168555770 cites W2083752666 @default.
- W3168555770 cites W2086618109 @default.
- W3168555770 cites W2086685901 @default.
- W3168555770 cites W2088649384 @default.
- W3168555770 cites W2089032508 @default.
- W3168555770 cites W2089834945 @default.