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• W3168558247 abstract "Abstract Learning to be safe is central for adaptive behaviour when threats are no longer present. Detecting the absence of an expected threat is key for threat extinction learning and an essential process for the behavioural treatment of anxiety related disorders. One possible mechanism underlying extinction learning is a dopaminergic mismatch signal that encodes the absence of an expected threat. Here we show that such a dopamine-related pathway underlies extinction learning in humans. Dopaminergic enhancement via administration of L-DOPA (vs. Placebo) was associated with reduced retention of differential psychophysiological threat responses at later test, which was mediated by activity in the ventromedial prefrontal cortex that was specific to extinction learning. L-DOPA administration enhanced signals at the time-point of an expected, but omitted threat in extinction learning within the nucleus accumbens, which were functionally coupled with the ventral tegmental area and the amygdala. Computational modelling of threat expectancies further revealed prediction error encoding in nucleus accumbens that was reduced when L-DOPA was administered. Our results thereby provide evidence that extinction learning is influenced by L-DOPA and provide a mechanistic perspective to augment extinction learning by dopaminergic enhancement in humans. Summary COI statement No conflict of interest for any of the authors. The funder had no role in the design of the study, the collection and analysis of data, or the preparation of the manuscript." @default.
• W3168558247 created "2021-06-22" @default.
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• W3168558247 date "2020-12-07" @default.
• W3168558247 modified "2023-09-25" @default.
• W3168558247 title "L-DOPA modulates activity in the vmPFC, Nucleus Accumbens and VTA during threat extinction learning in humans" @default.
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• W3168558247 doi "https://doi.org/10.1101/2020.12.07.414771" @default.
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