Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168589205> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W3168589205 endingPage "306" @default.
- W3168589205 startingPage "297" @default.
- W3168589205 abstract "Abstract Since the initial reports of activity of pembrolizumab in recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), investigation of the role of immune therapies has been the major focus of clinical trials in R/M HNSCC. Randomised trials initially with nivolumab and later with pembrolizumab established overall survival benefit in patients with R/M HNSCC previously treated with platinum compared to physicians choice of 2nd line therapy, and have led to regulatory approval around the world. More recently the Keynote-048 trial has compared both pembrolizumab monotherapy and pembrolizumab + platinum/5FU to the Extreme regimen of platinum/5FU/cetuximab in the first-line R/M setting. The key findings from this trial are that pembrolizumab monotherapy compared to Extreme improved overall survival in patients with PD-L1 combined positive score (CPS) ≥ 20 and ≥ 1, and that pembro/chemotherapy improved OS in CPS ≥ 20, CPS ≥ 1 and the total population. Relative to Extreme there was less toxicity in the monotherapy arm and comparable toxicity in the pembro/chemo arm. Based on this trial use of pembrolizumab as part of first-line treatment for R/M HNSCC is appropriate for the majority of patients, and represents a new standard of care. The focus has now moved to identifying combinations that may be superior to pembrolizumab monotherapy or to chemotherapy + pembrolizumab. Some of the more promising approaches under investigation in HNSCC are discussed in this chapter. In summary, immune therapies are now the cornerstone of management of R/M HNSCC with the approval of pembrolizumab in the first-line R/M setting." @default.
- W3168589205 created "2021-06-22" @default.
- W3168589205 creator A5060469120 @default.
- W3168589205 date "2021-01-01" @default.
- W3168589205 modified "2023-09-26" @default.
- W3168589205 title "Update of Immune Therapies in Recurrent/Metastatic Head and Neck Cancer" @default.
- W3168589205 cites W1952422131 @default.
- W3168589205 cites W2051482360 @default.
- W3168589205 cites W2109261874 @default.
- W3168589205 cites W2112845420 @default.
- W3168589205 cites W2166662937 @default.
- W3168589205 cites W2523194272 @default.
- W3168589205 cites W2529484692 @default.
- W3168589205 cites W2576461727 @default.
- W3168589205 cites W2711613673 @default.
- W3168589205 cites W2774533844 @default.
- W3168589205 cites W2782035861 @default.
- W3168589205 cites W2799372507 @default.
- W3168589205 cites W2892876553 @default.
- W3168589205 cites W2898717093 @default.
- W3168589205 cites W2902856530 @default.
- W3168589205 cites W2902963806 @default.
- W3168589205 cites W2903493423 @default.
- W3168589205 cites W2947709024 @default.
- W3168589205 cites W2967900707 @default.
- W3168589205 cites W2978537230 @default.
- W3168589205 cites W2978816287 @default.
- W3168589205 cites W2986633517 @default.
- W3168589205 cites W3001232216 @default.
- W3168589205 cites W3011919019 @default.
- W3168589205 cites W3015755028 @default.
- W3168589205 cites W4206795917 @default.
- W3168589205 cites W4235662528 @default.
- W3168589205 doi "https://doi.org/10.1007/978-3-030-63234-2_19" @default.
- W3168589205 hasPublicationYear "2021" @default.
- W3168589205 type Work @default.
- W3168589205 sameAs 3168589205 @default.
- W3168589205 citedByCount "0" @default.
- W3168589205 crossrefType "book-chapter" @default.
- W3168589205 hasAuthorship W3168589205A5060469120 @default.
- W3168589205 hasBestOaLocation W31685892051 @default.
- W3168589205 hasConcept C121608353 @default.
- W3168589205 hasConcept C126322002 @default.
- W3168589205 hasConcept C143998085 @default.
- W3168589205 hasConcept C2776530083 @default.
- W3168589205 hasConcept C2776833033 @default.
- W3168589205 hasConcept C2777701055 @default.
- W3168589205 hasConcept C2779998722 @default.
- W3168589205 hasConcept C2780030458 @default.
- W3168589205 hasConcept C2780057760 @default.
- W3168589205 hasConcept C2781413609 @default.
- W3168589205 hasConcept C2908647359 @default.
- W3168589205 hasConcept C526805850 @default.
- W3168589205 hasConcept C535046627 @default.
- W3168589205 hasConcept C71924100 @default.
- W3168589205 hasConcept C99454951 @default.
- W3168589205 hasConceptScore W3168589205C121608353 @default.
- W3168589205 hasConceptScore W3168589205C126322002 @default.
- W3168589205 hasConceptScore W3168589205C143998085 @default.
- W3168589205 hasConceptScore W3168589205C2776530083 @default.
- W3168589205 hasConceptScore W3168589205C2776833033 @default.
- W3168589205 hasConceptScore W3168589205C2777701055 @default.
- W3168589205 hasConceptScore W3168589205C2779998722 @default.
- W3168589205 hasConceptScore W3168589205C2780030458 @default.
- W3168589205 hasConceptScore W3168589205C2780057760 @default.
- W3168589205 hasConceptScore W3168589205C2781413609 @default.
- W3168589205 hasConceptScore W3168589205C2908647359 @default.
- W3168589205 hasConceptScore W3168589205C526805850 @default.
- W3168589205 hasConceptScore W3168589205C535046627 @default.
- W3168589205 hasConceptScore W3168589205C71924100 @default.
- W3168589205 hasConceptScore W3168589205C99454951 @default.
- W3168589205 hasLocation W31685892051 @default.
- W3168589205 hasLocation W31685892052 @default.
- W3168589205 hasOpenAccess W3168589205 @default.
- W3168589205 hasPrimaryLocation W31685892051 @default.
- W3168589205 hasRelatedWork W2092828699 @default.
- W3168589205 hasRelatedWork W2589134582 @default.
- W3168589205 hasRelatedWork W2607245858 @default.
- W3168589205 hasRelatedWork W2890180104 @default.
- W3168589205 hasRelatedWork W3000701650 @default.
- W3168589205 hasRelatedWork W3090002302 @default.
- W3168589205 hasRelatedWork W3181826502 @default.
- W3168589205 hasRelatedWork W3197484731 @default.
- W3168589205 hasRelatedWork W4360976231 @default.
- W3168589205 hasRelatedWork W2793630990 @default.
- W3168589205 isParatext "false" @default.
- W3168589205 isRetracted "false" @default.
- W3168589205 magId "3168589205" @default.
- W3168589205 workType "book-chapter" @default.