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- W3168595909 abstract "More than 40% of the risk of developing prostate cancer (PCa) is from genetic factors. Genome-wide association studies have led to the discovery of more than 140 variants associated with PCa risk. Polygenic risk scores (PRS) generated using these variants show promise in identifying individuals at much higher (and lower) lifetime risk than the average man. PCa PRS also improve the predictive value of prostate-specific antigen screening, may inform the age for starting PCa screening, and are informative for development of more aggressive tumors. Despite the promise, few clinical trials have evaluated the benefit of PCa PRS for clinical care." @default.
- W3168595909 created "2021-06-22" @default.
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- W3168595909 date "2021-08-01" @default.
- W3168595909 modified "2023-09-27" @default.
- W3168595909 title "Polygenic Risk Scores in Prostate Cancer Risk Assessment and Screening" @default.
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- W3168595909 doi "https://doi.org/10.1016/j.ucl.2021.03.007" @default.
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