FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168622161> ?p ?o ?g. }

• W3168622161 endingPage "e0252932" @default.
• W3168622161 startingPage "e0252932" @default.
• W3168622161 abstract "The mitochondrial tumor suppressor 1 (MTUS1) gene acts as a crucial tumor suppressor by inhibiting growth and proliferation of eukaryotic cells including tumor cell lines. Down regulation of MTUS1 gene has been implicated in a wide range of cancers as well as various human diseases. Alteration through nsSNPs can potentially damage the structure and/or function of the protein. As characterization of functional SNPs in such disease linked genes is a major challenge, it is feasible to analyze putative functional SNPs prior to performing larger population studies. Hence, in this in silico study we differentiated the potentially harmful nsSNPs of the MTUS1 gene from the neutral ones by using various sequence and structure based bioinformatic tools. In a total of 215 nsSNPs, 9 were found to be most likely to exert deleterious effect using 7 prediction tools. From which, 5nsSNPs (S1259L, E960K, P503T, L1084V and L1143Q) were selected as potentially damaging due to their presence in the highly conserved region and ability to decrease protein stability. In fact, 2 nsSNPs (S1259L and E960K) among these 5 were found to be individually associated with two distinctive cancers named Stomach adenocarcinoma and Uterine corpus endometrial carcinoma. As this is the first comprehensive study analyzing the functional nsSNPs of MTUS1, the results of the current study would certainly be helpful in future prospects concerning large population-based studies as well as drug discovery, especially developing individualized medicine." @default.
• W3168622161 created "2021-06-22" @default.
• W3168622161 creator A5049895519 @default.
• W3168622161 creator A5061818243 @default.
• W3168622161 creator A5070613144 @default.
• W3168622161 date "2021-06-14" @default.
• W3168622161 modified "2023-10-10" @default.
• W3168622161 title "In silico analysis of deleterious SNPs of human MTUS1 gene and their impacts on subsequent protein structure and function" @default.
• W3168622161 cites W1979349275 @default.
• W3168622161 cites W1980740976 @default.
• W3168622161 cites W1986191025 @default.
• W3168622161 cites W1987134040 @default.
• W3168622161 cites W1991269237 @default.
• W3168622161 cites W1991461625 @default.
• W3168622161 cites W1992192767 @default.
• W3168622161 cites W2005750609 @default.
• W3168622161 cites W2011094352 @default.
• W3168622161 cites W2024487267 @default.
• W3168622161 cites W2040904248 @default.
• W3168622161 cites W2048947745 @default.
• W3168622161 cites W2059145105 @default.
• W3168622161 cites W2089335658 @default.
• W3168622161 cites W2092338124 @default.
• W3168622161 cites W2099564671 @default.
• W3168622161 cites W2099693688 @default.
• W3168622161 cites W2102245393 @default.
• W3168622161 cites W2102993309 @default.
• W3168622161 cites W2112480941 @default.
• W3168622161 cites W2113613985 @default.
• W3168622161 cites W2114886480 @default.
• W3168622161 cites W2115108310 @default.
• W3168622161 cites W2122339645 @default.
• W3168622161 cites W2122732537 @default.
• W3168622161 cites W2128995100 @default.
• W3168622161 cites W2131638601 @default.
• W3168622161 cites W2132268436 @default.
• W3168622161 cites W2132752562 @default.
• W3168622161 cites W2133465259 @default.
• W3168622161 cites W2136117114 @default.
• W3168622161 cites W2136513422 @default.
• W3168622161 cites W2149195137 @default.
• W3168622161 cites W2149441684 @default.
• W3168622161 cites W2151778936 @default.
• W3168622161 cites W2159614853 @default.
• W3168622161 cites W2159896121 @default.
• W3168622161 cites W2165304304 @default.
• W3168622161 cites W2168621448 @default.
• W3168622161 cites W2288567390 @default.
• W3168622161 cites W2300696561 @default.
• W3168622161 cites W2401241322 @default.
• W3168622161 cites W2527628624 @default.
• W3168622161 cites W2607129810 @default.
• W3168622161 cites W2733572470 @default.
• W3168622161 cites W2737998151 @default.
• W3168622161 cites W2803684774 @default.
• W3168622161 cites W2804822363 @default.
• W3168622161 cites W2903826068 @default.
• W3168622161 cites W3082325112 @default.
• W3168622161 cites W3149510935 @default.
• W3168622161 cites W4232460528 @default.
• W3168622161 cites W4254753097 @default.
• W3168622161 doi "https://doi.org/10.1371/journal.pone.0252932" @default.
• W3168622161 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8202925" @default.
• W3168622161 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34125870" @default.
• W3168622161 hasPublicationYear "2021" @default.
• W3168622161 type Work @default.
• W3168622161 sameAs 3168622161 @default.
• W3168622161 citedByCount "11" @default.
• W3168622161 countsByYear W31686221612022 @default.
• W3168622161 countsByYear W31686221612023 @default.
• W3168622161 crossrefType "journal-article" @default.
• W3168622161 hasAuthorship W3168622161A5049895519 @default.
• W3168622161 hasAuthorship W3168622161A5061818243 @default.
• W3168622161 hasAuthorship W3168622161A5070613144 @default.
• W3168622161 hasBestOaLocation W31686221611 @default.
• W3168622161 hasConcept C104317684 @default.
• W3168622161 hasConcept C135763542 @default.
• W3168622161 hasConcept C153209595 @default.
• W3168622161 hasConcept C179185449 @default.
• W3168622161 hasConcept C2775905019 @default.
• W3168622161 hasConcept C2908647359 @default.
• W3168622161 hasConcept C54355233 @default.
• W3168622161 hasConcept C60644358 @default.
• W3168622161 hasConcept C70721500 @default.
• W3168622161 hasConcept C71924100 @default.
• W3168622161 hasConcept C86803240 @default.
• W3168622161 hasConcept C99454951 @default.
• W3168622161 hasConceptScore W3168622161C104317684 @default.
• W3168622161 hasConceptScore W3168622161C135763542 @default.
• W3168622161 hasConceptScore W3168622161C153209595 @default.
• W3168622161 hasConceptScore W3168622161C179185449 @default.
• W3168622161 hasConceptScore W3168622161C2775905019 @default.
• W3168622161 hasConceptScore W3168622161C2908647359 @default.
• W3168622161 hasConceptScore W3168622161C54355233 @default.
• W3168622161 hasConceptScore W3168622161C60644358 @default.
• W3168622161 hasConceptScore W3168622161C70721500 @default.
• W3168622161 hasConceptScore W3168622161C71924100 @default.
• W3168622161 hasConceptScore W3168622161C86803240 @default.

• next