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• W3168657415 abstract "Purpose: Currently, Canada is the only G8 country without a proton beam therapy (PBT) facility in operation or under construction. Based on experience from other G8 countries with PBT facilities, it has been estimated that approximately 5-16% of all cancer patients who receive radiation treatment with curative intent should be considered for PBT. To begin planning for a PBT facility in Ontario, a more robust and localized estimate of the need for PBT is required. Methods: An expert panel was assembled to develop an estimate of the need for PBT services. A step-wise approach was taken to: 1) identify clinical indications for PBT; 2) obtain volume estimates for curative photon therapy for select practice site groups and patient subpopulations (pediatric, adolescent young adult and adult); 3) develop and apply clinical algorithms to estimate the proportion of each indication that should be considered for PBT. Data was gathered from program level reporting and published literature. Expert opinion and consensus further informed decision-making. Results: 13 practice site groups for which PBT could have potential clinical benefit were identified: benign neoplasms, breast, central nervous system, endocrine, gastrointestinal, genitourinary, gynecological, hematology, head and neck, lung, other cancers, sarcoma, and skin. The largest variation in practice site estimates across subpopulations were found in endocrine, breast, gastrointestinal, sarcoma, and skin. Applying expert panel proportion estimates to curative radiation treatment volumes gathered from program level reporting for the respective practice groups and subpopulations (n=27,500), the estimated provincial need for PBT is 1,542 (5.6%) patients per year, with a lower bound of 364 (1.32%) and an upper bound of 4,246 (15.44%). Conclusions: An Ontario PBT facility has the potential to provide equitable access to comprehensive cancer care; decreasing long-term toxicities, improving patient experience and health outcomes. With limited published data in the Canadian context of an estimated need for Proton Beam Therapy, the methodology described provides a more robust estimate of the need for PBT. This methodology can be applied across other jurisdictions to assist with PBT planning exercises." @default.
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• W3168657415 date "2021-06-01" @default.
• W3168657415 modified "2023-10-16" @default.
• W3168657415 title "A Novel Methodology to Estimate the Need for Proton Beam Therapy" @default.
• W3168657415 doi "https://doi.org/10.1016/j.jmir.2021.03.014" @default.
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