Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168673693> ?p ?o ?g. }
- W3168673693 endingPage "e202000928" @default.
- W3168673693 startingPage "e202000928" @default.
- W3168673693 abstract "Recent studies suggested that dysregulated YY1 plays a pivotal role in many liver diseases. To obtain a detailed view of genes and pathways regulated by YY1 in the liver, we carried out RNA sequencing in HepG2 cells after YY1 knockdown. A rigid set of 2,081 differentially expressed genes was identified by comparing the YY1-knockdown samples (n = 8) with the control samples (n = 14). YY1 knockdown significantly decreased the expression of several key transcription factors and their coactivators in lipid metabolism. This is illustrated by YY1 regulating PPARA expression through binding to its promoter and enhancer regions. Our study further suggest that down-regulation of the key transcription factors together with YY1 knockdown significantly decreased the cooperation between YY1 and these transcription factors at various regulatory regions, which are important in regulating the expression of genes in hepatic lipid metabolism. This was supported by the finding that the expression of SCD and ELOVL6 , encoding key enzymes in lipogenesis, were regulated by the cooperation between YY1 and PPARA/RXRA complex over their promoters." @default.
- W3168673693 created "2021-06-22" @default.
- W3168673693 creator A5009757802 @default.
- W3168673693 creator A5040276109 @default.
- W3168673693 creator A5045645676 @default.
- W3168673693 creator A5050406527 @default.
- W3168673693 creator A5062357087 @default.
- W3168673693 creator A5066763304 @default.
- W3168673693 date "2021-06-07" @default.
- W3168673693 modified "2023-10-09" @default.
- W3168673693 title "Multifaceted regulation of hepatic lipid metabolism by YY1" @default.
- W3168673693 cites W1967717006 @default.
- W3168673693 cites W1974744093 @default.
- W3168673693 cites W2002122781 @default.
- W3168673693 cites W2020814081 @default.
- W3168673693 cites W2023104601 @default.
- W3168673693 cites W2024217191 @default.
- W3168673693 cites W2033023998 @default.
- W3168673693 cites W2035618305 @default.
- W3168673693 cites W2045175945 @default.
- W3168673693 cites W2054158156 @default.
- W3168673693 cites W2072362233 @default.
- W3168673693 cites W2078336790 @default.
- W3168673693 cites W2088929386 @default.
- W3168673693 cites W2091544680 @default.
- W3168673693 cites W2098012175 @default.
- W3168673693 cites W2099110406 @default.
- W3168673693 cites W2100761975 @default.
- W3168673693 cites W2104467529 @default.
- W3168673693 cites W2106509101 @default.
- W3168673693 cites W2107580398 @default.
- W3168673693 cites W2108234281 @default.
- W3168673693 cites W2116351973 @default.
- W3168673693 cites W2117822509 @default.
- W3168673693 cites W2130410032 @default.
- W3168673693 cites W2137508759 @default.
- W3168673693 cites W2138207763 @default.
- W3168673693 cites W2164153195 @default.
- W3168673693 cites W2169510176 @default.
- W3168673693 cites W2170830174 @default.
- W3168673693 cites W2174107467 @default.
- W3168673693 cites W2179438025 @default.
- W3168673693 cites W2179972854 @default.
- W3168673693 cites W2259938310 @default.
- W3168673693 cites W2341539131 @default.
- W3168673693 cites W2342245373 @default.
- W3168673693 cites W2345356016 @default.
- W3168673693 cites W2395662745 @default.
- W3168673693 cites W2520717521 @default.
- W3168673693 cites W2561182005 @default.
- W3168673693 cites W2602059628 @default.
- W3168673693 cites W2768491523 @default.
- W3168673693 cites W2774733631 @default.
- W3168673693 cites W2775505403 @default.
- W3168673693 cites W2777933743 @default.
- W3168673693 cites W2779202009 @default.
- W3168673693 cites W2802682732 @default.
- W3168673693 cites W2810423511 @default.
- W3168673693 cites W2889932786 @default.
- W3168673693 cites W2893835498 @default.
- W3168673693 cites W2894916360 @default.
- W3168673693 cites W2902086897 @default.
- W3168673693 cites W2964849163 @default.
- W3168673693 cites W2982624777 @default.
- W3168673693 cites W2990536257 @default.
- W3168673693 cites W2998849619 @default.
- W3168673693 cites W4231254854 @default.
- W3168673693 cites W4237381349 @default.
- W3168673693 doi "https://doi.org/10.26508/lsa.202000928" @default.
- W3168673693 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8200296" @default.
- W3168673693 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34099540" @default.
- W3168673693 hasPublicationYear "2021" @default.
- W3168673693 type Work @default.
- W3168673693 sameAs 3168673693 @default.
- W3168673693 citedByCount "12" @default.
- W3168673693 countsByYear W31686736932021 @default.
- W3168673693 countsByYear W31686736932022 @default.
- W3168673693 countsByYear W31686736932023 @default.
- W3168673693 crossrefType "journal-article" @default.
- W3168673693 hasAuthorship W3168673693A5009757802 @default.
- W3168673693 hasAuthorship W3168673693A5040276109 @default.
- W3168673693 hasAuthorship W3168673693A5045645676 @default.
- W3168673693 hasAuthorship W3168673693A5050406527 @default.
- W3168673693 hasAuthorship W3168673693A5062357087 @default.
- W3168673693 hasAuthorship W3168673693A5066763304 @default.
- W3168673693 hasBestOaLocation W31686736931 @default.
- W3168673693 hasConcept C101762097 @default.
- W3168673693 hasConcept C104317684 @default.
- W3168673693 hasConcept C111936080 @default.
- W3168673693 hasConcept C138885662 @default.
- W3168673693 hasConcept C141359234 @default.
- W3168673693 hasConcept C150194340 @default.
- W3168673693 hasConcept C165864922 @default.
- W3168673693 hasConcept C173396325 @default.
- W3168673693 hasConcept C179926584 @default.
- W3168673693 hasConcept C27153228 @default.
- W3168673693 hasConcept C41895202 @default.
- W3168673693 hasConcept C4733338 @default.