FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168695115> ?p ?o ?g. }

• W3168695115 endingPage "562" @default.
• W3168695115 startingPage "550" @default.
• W3168695115 abstract "BackgroundPrevalence rates of opioid use disorder (OUD) have increased dramatically, accompanied by a surge of overdose deaths. While opioid dependence has been extensively studied in preclinical models, an understanding of the biological alterations that occur in the brains of people who chronically use opioids and who are diagnosed with OUD remains limited. To address this limitation, RNA sequencing was conducted on the dorsolateral prefrontal cortex and nucleus accumbens, regions heavily implicated in OUD, from postmortem brains in subjects with OUD.MethodsWe performed RNA sequencing on the dorsolateral prefrontal cortex and nucleus accumbens from unaffected comparison subjects (n = 20) and subjects diagnosed with OUD (n = 20). Our transcriptomic analyses identified differentially expressed transcripts and investigated the transcriptional coherence between brain regions using rank-rank hypergeometric orderlap. Weighted gene coexpression analyses identified OUD-specific modules and gene networks. Integrative analyses between differentially expressed transcripts and genome-wide association study datasets using linkage disequilibrium scores assessed the genetic liability of psychiatric-related phenotypes in OUD.ResultsRank-rank hypergeometric overlap analyses revealed extensive overlap in transcripts between the dorsolateral prefrontal cortex and nucleus accumbens in OUD, related to synaptic remodeling and neuroinflammation. Identified transcripts were enriched for factors that control proinflammatory cytokine, chondroitin sulfate, and extracellular matrix signaling. Cell-type deconvolution implicated a role for microglia as a potential driver for opioid-induced neuroplasticity. Linkage disequilibrium score analysis suggested genetic liabilities for risky behavior, attention-deficit/hyperactivity disorder, and depression in subjects with OUD.ConclusionsOverall, our findings suggest connections between the brain’s immune system and opioid dependence in the human brain." @default.
• W3168695115 created "2021-06-22" @default.
• W3168695115 creator A5010309401 @default.
• W3168695115 creator A5013792187 @default.
• W3168695115 creator A5023821329 @default.
• W3168695115 creator A5028309539 @default.
• W3168695115 creator A5033522944 @default.
• W3168695115 creator A5041804176 @default.
• W3168695115 creator A5042915991 @default.
• W3168695115 creator A5046410151 @default.
• W3168695115 creator A5047091057 @default.
• W3168695115 creator A5057969622 @default.
• W3168695115 creator A5076664123 @default.
• W3168695115 creator A5076681397 @default.
• W3168695115 creator A5079371001 @default.
• W3168695115 creator A5079448584 @default.
• W3168695115 creator A5090281156 @default.
• W3168695115 date "2021-10-01" @default.
• W3168695115 modified "2023-10-16" @default.
• W3168695115 title "Transcriptional Alterations in Dorsolateral Prefrontal Cortex and Nucleus Accumbens Implicate Neuroinflammation and Synaptic Remodeling in Opioid Use Disorder" @default.
• W3168695115 cites W1165970735 @default.
• W3168695115 cites W1590629056 @default.
• W3168695115 cites W1863734307 @default.
• W3168695115 cites W1869322032 @default.
• W3168695115 cites W1869906673 @default.
• W3168695115 cites W1957795404 @default.
• W3168695115 cites W1964351040 @default.
• W3168695115 cites W1966476186 @default.
• W3168695115 cites W1967181972 @default.
• W3168695115 cites W1970466571 @default.
• W3168695115 cites W1974157342 @default.
• W3168695115 cites W1975670052 @default.
• W3168695115 cites W1980485021 @default.
• W3168695115 cites W1980640942 @default.
• W3168695115 cites W1988201936 @default.
• W3168695115 cites W1988926385 @default.
• W3168695115 cites W1991919291 @default.
• W3168695115 cites W1994390421 @default.
• W3168695115 cites W1995301808 @default.
• W3168695115 cites W1997218140 @default.
• W3168695115 cites W2000825812 @default.
• W3168695115 cites W2002642921 @default.
• W3168695115 cites W2011353038 @default.
• W3168695115 cites W2014677321 @default.
• W3168695115 cites W2016441739 @default.
• W3168695115 cites W2018398784 @default.
• W3168695115 cites W2019653257 @default.
• W3168695115 cites W2020346080 @default.
• W3168695115 cites W2022452786 @default.
• W3168695115 cites W2023680518 @default.
• W3168695115 cites W2030593831 @default.
• W3168695115 cites W2034348223 @default.
• W3168695115 cites W2038050935 @default.
• W3168695115 cites W2038672096 @default.
• W3168695115 cites W2042014897 @default.
• W3168695115 cites W2043528547 @default.
• W3168695115 cites W2044346852 @default.
• W3168695115 cites W2048924547 @default.
• W3168695115 cites W2053391380 @default.
• W3168695115 cites W2054378237 @default.
• W3168695115 cites W2054461128 @default.
• W3168695115 cites W2060705109 @default.
• W3168695115 cites W2071140375 @default.
• W3168695115 cites W2075480738 @default.
• W3168695115 cites W2076154138 @default.
• W3168695115 cites W2085848150 @default.
• W3168695115 cites W2088446288 @default.
• W3168695115 cites W2089489291 @default.
• W3168695115 cites W2090384073 @default.
• W3168695115 cites W2090804892 @default.
• W3168695115 cites W2105495527 @default.
• W3168695115 cites W2106315421 @default.
• W3168695115 cites W2106438910 @default.
• W3168695115 cites W2106877484 @default.
• W3168695115 cites W2106973613 @default.
• W3168695115 cites W2108033883 @default.
• W3168695115 cites W2111065008 @default.
• W3168695115 cites W2115632097 @default.
• W3168695115 cites W2124343538 @default.
• W3168695115 cites W2126228551 @default.
• W3168695115 cites W2129143684 @default.
• W3168695115 cites W2132832769 @default.
• W3168695115 cites W2136337975 @default.
• W3168695115 cites W2140872638 @default.
• W3168695115 cites W2146919072 @default.
• W3168695115 cites W2148859282 @default.
• W3168695115 cites W2152268051 @default.
• W3168695115 cites W2153860431 @default.
• W3168695115 cites W2154991670 @default.
• W3168695115 cites W2156247618 @default.
• W3168695115 cites W2165387836 @default.
• W3168695115 cites W2218838944 @default.
• W3168695115 cites W2252859017 @default.
• W3168695115 cites W2286805151 @default.
• W3168695115 cites W2353111961 @default.
• W3168695115 cites W2396403517 @default.
• W3168695115 cites W2403416022 @default.
• W3168695115 cites W2481599726 @default.

• next