Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168800908> ?p ?o ?g. }
- W3168800908 endingPage "101276" @default.
- W3168800908 startingPage "101276" @default.
- W3168800908 abstract "Acquired bone marrow failure (BMF) syndromes comprise a diverse group of diseases with variable clinical manifestations but overlapping features of immune activation, resulting in haematopoietic stem and progenitor cells (HSPC) damage and destruction. This review focuses on clinical presentation, pathophysiology, and treatment of four BMF: acquired aplastic anaemia, large granular lymphocytic leukaemia, paroxysmal nocturnal haemoglobinuria, and hypoplastic myelodysplastic syndrome. Autoantigens are speculated to be the inciting event that result in immune activation in all of these diseases, but specific pathogenic antigens have not been identified. Oligoclonal cytotoxic T cell expansion and an active role of proinflammatory cytokines, primarily interferon gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α), are two main contributors to HSPC growth inhibition and apoptosis in BMF. Emerging evidence also suggests involvement of the innate immune system." @default.
- W3168800908 created "2021-06-22" @default.
- W3168800908 creator A5037687084 @default.
- W3168800908 creator A5072063614 @default.
- W3168800908 creator A5086126385 @default.
- W3168800908 date "2021-06-01" @default.
- W3168800908 modified "2023-09-30" @default.
- W3168800908 title "Immunologic effects on the haematopoietic stem cell in marrow failure" @default.
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