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- W3168804981 abstract "A high proportion of depressed patients fail to respond to antidepressant drug treatment. Treatment-resistant depression (TRD) is a major challenge for the psychopharmacology of mood disorders. Only in the past decade have novel treatments, including deep brain stimulation (DBS) and ketamine, been discovered that provide rapid and sometimes prolonged relief to a high proportion of TRD sufferers. In this review, we consider the current status of TRD from four perspectives: the challenge of developing an appropriate regulatory framework for novel rapidly acting antidepressants; the efficacy of non-pharmacological somatic therapies; the development of an animal model of TRD and its use to understand the neural basis of antidepressant non-response; and the potential for rapid antidepressant action from targets (such as 5-HT1A receptors) beyond the glutamate receptor. LINKED ARTICLES: This article is part of a themed issue on New discoveries and perspectives in mental and pain disorders. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.17/issuetoc." @default.
- W3168804981 created "2021-06-22" @default.
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- W3168804981 creator A5061886376 @default.
- W3168804981 creator A5070339940 @default.
- W3168804981 date "2021-07-29" @default.
- W3168804981 modified "2023-10-16" @default.
- W3168804981 title "Perspectives for therapy of treatment‐resistant depression" @default.
- W3168804981 cites W1568270351 @default.
- W3168804981 cites W1588173517 @default.
- W3168804981 cites W1667725090 @default.
- W3168804981 cites W1746596066 @default.
- W3168804981 cites W1812482953 @default.
- W3168804981 cites W1914381346 @default.
- W3168804981 cites W1942655249 @default.
- W3168804981 cites W1943873295 @default.
- W3168804981 cites W1965965542 @default.
- W3168804981 cites W1966173192 @default.
- W3168804981 cites W1966449086 @default.
- W3168804981 cites W1971520303 @default.
- W3168804981 cites W1975182501 @default.
- W3168804981 cites W1977430165 @default.
- W3168804981 cites W1978926207 @default.
- W3168804981 cites W1984815383 @default.
- W3168804981 cites W1987239750 @default.
- W3168804981 cites W1991912111 @default.
- W3168804981 cites W1992584151 @default.
- W3168804981 cites W1992963529 @default.
- W3168804981 cites W1995331365 @default.
- W3168804981 cites W2003443050 @default.
- W3168804981 cites W2004624418 @default.
- W3168804981 cites W2006460397 @default.
- W3168804981 cites W2010167850 @default.
- W3168804981 cites W2010834169 @default.
- W3168804981 cites W2012910730 @default.
- W3168804981 cites W2013958954 @default.
- W3168804981 cites W2014192652 @default.
- W3168804981 cites W2017208437 @default.
- W3168804981 cites W2018378637 @default.
- W3168804981 cites W2023081218 @default.
- W3168804981 cites W2023619652 @default.
- W3168804981 cites W2024380057 @default.
- W3168804981 cites W2025204726 @default.
- W3168804981 cites W2025543055 @default.
- W3168804981 cites W2027505961 @default.
- W3168804981 cites W2028892374 @default.
- W3168804981 cites W2032739515 @default.
- W3168804981 cites W2033476752 @default.
- W3168804981 cites W2041036432 @default.
- W3168804981 cites W2043886872 @default.
- W3168804981 cites W2044069216 @default.
- W3168804981 cites W2045595011 @default.
- W3168804981 cites W2046140176 @default.
- W3168804981 cites W2054154385 @default.
- W3168804981 cites W2054695075 @default.
- W3168804981 cites W2055096975 @default.
- W3168804981 cites W2064214329 @default.
- W3168804981 cites W2067469284 @default.
- W3168804981 cites W2069096415 @default.
- W3168804981 cites W2071485618 @default.
- W3168804981 cites W2073935709 @default.
- W3168804981 cites W2080092700 @default.
- W3168804981 cites W2080458393 @default.
- W3168804981 cites W2083549526 @default.
- W3168804981 cites W2087002084 @default.
- W3168804981 cites W2089351762 @default.
- W3168804981 cites W2091155334 @default.
- W3168804981 cites W2098761489 @default.
- W3168804981 cites W2103255996 @default.
- W3168804981 cites W2103903531 @default.
- W3168804981 cites W2103993985 @default.
- W3168804981 cites W2106106014 @default.
- W3168804981 cites W2109334244 @default.
- W3168804981 cites W2120086835 @default.
- W3168804981 cites W2121358117 @default.
- W3168804981 cites W2125897705 @default.
- W3168804981 cites W2127191523 @default.
- W3168804981 cites W2129506769 @default.
- W3168804981 cites W2130136912 @default.
- W3168804981 cites W2132324173 @default.
- W3168804981 cites W2132969335 @default.
- W3168804981 cites W2136228108 @default.
- W3168804981 cites W2138114150 @default.
- W3168804981 cites W2144269887 @default.
- W3168804981 cites W2146978055 @default.
- W3168804981 cites W2148154633 @default.
- W3168804981 cites W2149402043 @default.
- W3168804981 cites W2163419022 @default.
- W3168804981 cites W2165484516 @default.
- W3168804981 cites W2171340584 @default.
- W3168804981 cites W2171752682 @default.
- W3168804981 cites W2179425605 @default.
- W3168804981 cites W2182104458 @default.
- W3168804981 cites W2206080083 @default.
- W3168804981 cites W2231648340 @default.
- W3168804981 cites W2266819934 @default.