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- W3168858712 abstract "β-blockers are a heterogeneous class of drugs, with varying selectivity/specificity for β1 vs β2 receptors, intrinsic sympathomimetic activity (ISA), and vasodilatory properties (through β2 stimulation, α receptor blockade or nitric oxide release). These drugs are indicated for the management of arterial hypertension, heart failure or ischemic heart disease (IHD; eg angina pectoris or prior myocardial infarction). Most of the benefit of β-blockade in these conditions arises from blockade of the β1 receptor, and, in practice, the addition of ISA appears to reduce the potential for improved clinical outcomes in people with heart failure or IHD. Aspects of the benefit/risk balance of β-blockers remain controversial, and recent meta-analyses have shed new light on this issue. We have reviewed the current place of cardioselective β-blockade in hypertension, IHD and heart failure, with special reference to the therapeutic profile of a highly selective β1-adrenoceptor blocker, bisoprolol." @default.
- W3168858712 created "2021-06-22" @default.
- W3168858712 creator A5027212688 @default.
- W3168858712 creator A5066832095 @default.
- W3168858712 date "2021-06-01" @default.
- W3168858712 modified "2023-09-25" @default.
- W3168858712 title "β-Blockade for Patients with Hypertension, Ischemic Heart Disease or Heart Failure: Where are We Now?" @default.
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- W3168858712 doi "https://doi.org/10.2147/vhrm.s285907" @default.
- W3168858712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8197620" @default.
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- W3168858712 hasPublicationYear "2021" @default.
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