FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168940517> ?p ?o ?g. }

• W3168940517 endingPage "1771.e13" @default.
• W3168940517 startingPage "1758" @default.
• W3168940517 abstract "Deubiquitinating enzymes (DUBs) are a class of isopeptidases that regulate ubiquitin dynamics through catalytic cleavage of ubiquitin from protein substrates and ubiquitin precursors. Despite growing interest in DUB biological function and potential as therapeutic targets, few selective small-molecule inhibitors and no approved drugs currently exist. To identify chemical scaffolds targeting specific DUBs and establish a broader framework for future inhibitor development across the gene family, we performed high-throughput screening of a chemically diverse small-molecule library against eight different DUBs, spanning three well-characterized DUB families. Promising hit compounds were validated in a series of counter-screens and orthogonal assays, as well as further assessed for selectivity across expanded panels of DUBs. Through these efforts, we have identified multiple highly selective DUB inhibitors and developed a roadmap for rapidly identifying and validating selective inhibitors of related enzymes." @default.
• W3168940517 created "2021-06-22" @default.
• W3168940517 creator A5001164647 @default.
• W3168940517 creator A5005522334 @default.
• W3168940517 creator A5010173370 @default.
• W3168940517 creator A5011985289 @default.
• W3168940517 creator A5016538103 @default.
• W3168940517 creator A5027584754 @default.
• W3168940517 creator A5030987306 @default.
• W3168940517 creator A5036621925 @default.
• W3168940517 creator A5045018731 @default.
• W3168940517 creator A5071694698 @default.
• W3168940517 creator A5074563113 @default.
• W3168940517 creator A5080526879 @default.
• W3168940517 creator A5083033053 @default.
• W3168940517 date "2021-12-01" @default.
• W3168940517 modified "2023-10-01" @default.
• W3168940517 title "Identification and validation of selective deubiquitinase inhibitors" @default.
• W3168940517 cites W1421935743 @default.
• W3168940517 cites W1565539350 @default.
• W3168940517 cites W1590553747 @default.
• W3168940517 cites W1618846043 @default.
• W3168940517 cites W1975715657 @default.
• W3168940517 cites W1995747121 @default.
• W3168940517 cites W1997945562 @default.
• W3168940517 cites W2008310735 @default.
• W3168940517 cites W2012296420 @default.
• W3168940517 cites W2032997281 @default.
• W3168940517 cites W2034894297 @default.
• W3168940517 cites W2043509228 @default.
• W3168940517 cites W2048667125 @default.
• W3168940517 cites W2058065156 @default.
• W3168940517 cites W2062458432 @default.
• W3168940517 cites W2062801508 @default.
• W3168940517 cites W2087608460 @default.
• W3168940517 cites W2088767253 @default.
• W3168940517 cites W2091489626 @default.
• W3168940517 cites W2097559461 @default.
• W3168940517 cites W2108455455 @default.
• W3168940517 cites W2124348590 @default.
• W3168940517 cites W2125243526 @default.
• W3168940517 cites W2129805026 @default.
• W3168940517 cites W2134404356 @default.
• W3168940517 cites W2135732933 @default.
• W3168940517 cites W2136128861 @default.
• W3168940517 cites W2139364069 @default.
• W3168940517 cites W2139592339 @default.
• W3168940517 cites W2143322707 @default.
• W3168940517 cites W2145311451 @default.
• W3168940517 cites W2145967523 @default.
• W3168940517 cites W2146657624 @default.
• W3168940517 cites W2147973026 @default.
• W3168940517 cites W2150925238 @default.
• W3168940517 cites W2151683271 @default.
• W3168940517 cites W2153891907 @default.
• W3168940517 cites W2158359547 @default.
• W3168940517 cites W2163229353 @default.
• W3168940517 cites W2165688553 @default.
• W3168940517 cites W2165724726 @default.
• W3168940517 cites W2170481384 @default.
• W3168940517 cites W2283442479 @default.
• W3168940517 cites W2308104112 @default.
• W3168940517 cites W2309366384 @default.
• W3168940517 cites W2314262285 @default.
• W3168940517 cites W2409179396 @default.
• W3168940517 cites W2470671857 @default.
• W3168940517 cites W2495215685 @default.
• W3168940517 cites W2534229385 @default.
• W3168940517 cites W2534266625 @default.
• W3168940517 cites W2593436234 @default.
• W3168940517 cites W2607355686 @default.
• W3168940517 cites W2613065881 @default.
• W3168940517 cites W2731879246 @default.
• W3168940517 cites W2757682641 @default.
• W3168940517 cites W2763470412 @default.
• W3168940517 cites W2765585400 @default.
• W3168940517 cites W2766422151 @default.
• W3168940517 cites W2766738665 @default.
• W3168940517 cites W2769430476 @default.
• W3168940517 cites W2772653075 @default.
• W3168940517 cites W2775382512 @default.
• W3168940517 cites W2789777795 @default.
• W3168940517 cites W2790295680 @default.
• W3168940517 cites W2792227597 @default.
• W3168940517 cites W2793198937 @default.
• W3168940517 cites W2799755181 @default.
• W3168940517 cites W2884272629 @default.
• W3168940517 cites W2887049666 @default.
• W3168940517 cites W2892288934 @default.
• W3168940517 cites W2901826882 @default.
• W3168940517 cites W2922956498 @default.
• W3168940517 cites W2923891491 @default.
• W3168940517 cites W2952615074 @default.
• W3168940517 cites W2952907530 @default.
• W3168940517 cites W2967883380 @default.
• W3168940517 cites W2984350850 @default.
• W3168940517 cites W3009261305 @default.
• W3168940517 cites W3010998686 @default.

• next