Matches in SemOpenAlex for { <https://semopenalex.org/work/W3168968023> ?p ?o ?g. }
- W3168968023 abstract "Regulatory T cells (T regs ) are key immunosuppressive cells that promote tumor growth by hindering the effector immune response. T regs utilize multiple suppressive mechanisms to inhibit pro-inflammatory responses within the tumor microenvironment (TME) by inhibition of effector function and immune cell migration, secretion of inhibitory cytokines, metabolic disruption and promotion of metastasis. In turn, T regs are being targeted in the clinic either alone or in combination with other immunotherapies, in efforts to overcome the immunosuppressive TME and increase anti-tumor effects. However, it is now appreciated that T regs not only suppress cells intratumorally via direct engagement, but also serve as key interactors in the peritumor, stroma, vasculature and lymphatics to limit anti-tumor immune responses prior to tumor infiltration. We will review the suppressive mechanisms that T regs utilize to alter immune and non-immune cells outside and within the TME and discuss how these mechanisms collectively allow T regs to create and promote a physical and biological barrier, resulting in an immune-excluded or limited tumor microenvironment." @default.
- W3168968023 created "2021-06-22" @default.
- W3168968023 creator A5008106149 @default.
- W3168968023 creator A5038152682 @default.
- W3168968023 creator A5047331973 @default.
- W3168968023 creator A5057829178 @default.
- W3168968023 date "2021-06-10" @default.
- W3168968023 modified "2023-10-17" @default.
- W3168968023 title "Regulatory T Cells: Barriers of Immune Infiltration Into the Tumor Microenvironment" @default.
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