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- W3168980156 abstract "Epidemiologic studies have shown that an increase in the dietary intake of tomato and tomato-based products or higher blood levels of lycopene, is associated with a reduced risk of cancer. Apolycopenoids can be produced by either lycopene cleavage through carotenoid cleavage enzymes, such as beta-carotene 9′,10′-oxygenase or the consumption of tomato and tomato products, such as tomato juice. We have previously shown that apo-10′-lycopenoic acid, a relative stable derivative of apo-10′-lycopenoids, could inhibit tumorigenesis in both lung cancer and liver cancer animal models. To further elucidate the potential mechanisms for the chemopreventive effect of apo-10′-lycopenoic acid against cancer development, we examined the ability of apo-10′-lycopenoic acid on migration of cancer cells (A549 and HuH7 cells) and endothelial cells (HMEC-1) using cell migration assays, and angiogenesis using endothelial tube formation and aortic ring assays. We demonstrated that apo-10′-lycopenoic acid, in dose-dependent manner, is effective at inhibiting migration and invasion of both cancer and endothelial cells by suppressing actin remodeling and ruffling/lamellipodia formation. In addition, apo-10-lycopenoic acid treatment results in suppression of angiogenesis in both tube formation and aortic ring assays. Apo-10-lycopenoic acid also inhibits matrix metalloproteinase-2 (MMP-2) expression and activation in A549 cells. Overall, these data demonstrate that apo-10′-lycopenoic acid can inhibit cancer cell motility and angiogenesis which could be one of the potential mechanisms for the chemopreventive effect of apo-10′-lycopenoic acid against tumorigenesis. Support or Funding Information Supported by USDA/ARS (58-1950-0014)" @default.
- W3168980156 created "2021-06-22" @default.
- W3168980156 creator A5020299359 @default.
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- W3168980156 date "2016-04-01" @default.
- W3168980156 modified "2023-09-25" @default.
- W3168980156 title "Apo‐10′‐Lycopenoic acid Inhibits Cancer Cell Migration and Angiogenesis by Suppressing Lamellipodia Formation" @default.
- W3168980156 doi "https://doi.org/10.1096/fasebj.30.1_supplement.689.8" @default.
- W3168980156 hasPublicationYear "2016" @default.
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