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• W3169054583 abstract "The importance of multivalency for N-glycan-protein interactions has primarily been studied by attachment of minimal epitopes to artificial multivalent scaffold and not in the context of multi-antennary glycans. N-glycans can be modified by bisecting GlcNAc, core xylosides and fucosides, and extended N-acetyl lactosamine moieties. The impact of such modifications on glycan recognition are also not well understood. We describe here a chemoenzymatic methodology that can provide N-glycans expressed by the parasitic worm S. mansoni having unique epitopes at each antenna and containing core xyloside. NMR, computational and electron microscopy were employed to investigate recognition of the glycans by the human lectin DC-SIGN. It revealed that core xyloside does not influence terminal epitope recognition. The multi-antennary glycans bound with higher affinity to DC-SIGN compared to mono-valent counterparts, which was attributed to proximity-induced effective concentration. The multi-antennary glycans cross-linked DC-SIGN into a dense network, which likely is relevant for antigen uptake and intracellular routing." @default.
• W3169054583 created "2021-06-22" @default.
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• W3169054583 date "2021-07-16" @default.
• W3169054583 modified "2023-10-17" @default.
• W3169054583 title "Chemoenzymatic Synthesis of Complex <i>N</i> ‐Glycans of the Parasite <i>S. mansoni</i> to Examine the Importance of Epitope Presentation on DC‐SIGN recognition" @default.
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• W3169054583 doi "https://doi.org/10.1002/anie.202105647" @default.
• W3169054583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8456914" @default.
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