FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3169056896> ?p ?o ?g. }

• W3169056896 abstract "Abstract Background Mucosal sites are hypothesized to play a role in the development of rheumatoid arthritis (RA). Since serum anti-peptidylarginine deiminase (PAD)4 antibodies, including a subset that cross-react with PAD3 (PAD3/4), are specific for RA and associate with severe disease, we sought to examine whether anti-PAD4 and anti-PAD3/4 antibodies were present in the lung and oral mucosa of subjects with RA and “at-risk” for RA. Methods We included 37 RA, 25 healthy control, and 46 subjects “at-risk” for RA based on familial RA and/or serum anti-citrullinated protein antibody (ACPA) positivity. Paired serum, sputum, and saliva were evaluated for anti-PAD4 and anti-PAD3/4 using immunoprecipitation and ACPA using ELISA. Immunoglobulins (Ig) were purified from representative samples, and their effect on citrullination of histone H3 by recombinant human PAD4 was measured by anti-citH3 immunoblot. Results Anti-PAD4 antibodies were detected in the serum of 6/37 (16.2%), sputum of 3/37 (8.1%), and saliva of 3/33 (9.1%) RA subjects and in the serum and sputum of 1/46 (2.2%) at-risk subjects. None of the healthy controls had anti-PAD4 antibodies at any site. Serum, sputum, and salivary anti-PAD4 antibodies were more prevalent in RA subjects with RA duration >2 years. Purified antibodies from representative anti-PAD4-positive and anti-PAD3/4-positive sputum were primarily of the IgA isotype and able to increase PAD4 enzymatic activity. Conclusions Anti-PAD4 antibodies are present in the sputum and saliva of a portion of RA patients and are infrequent in at-risk subjects. Importantly, the ability of anti-PAD4, and particularly anti-PAD3/4, antibodies in the sputum to enhance PAD4 enzymatic activity suggests that anti-PAD4 may play an active role in the RA lung." @default.
• W3169056896 created "2021-06-22" @default.
• W3169056896 creator A5011051142 @default.
• W3169056896 creator A5011886992 @default.
• W3169056896 creator A5017259150 @default.
• W3169056896 creator A5033020983 @default.
• W3169056896 creator A5040063597 @default.
• W3169056896 creator A5045733957 @default.
• W3169056896 creator A5057205976 @default.
• W3169056896 creator A5077400124 @default.
• W3169056896 creator A5089817311 @default.
• W3169056896 date "2021-06-06" @default.
• W3169056896 modified "2023-10-05" @default.
• W3169056896 title "Anti-peptidylarginine deiminase-4 antibodies at mucosal sites can activate peptidylarginine deiminase-4 enzyme activity in rheumatoid arthritis" @default.
• W3169056896 cites W1901640178 @default.
• W3169056896 cites W1980379994 @default.
• W3169056896 cites W1983929025 @default.
• W3169056896 cites W2031073334 @default.
• W3169056896 cites W2082888832 @default.
• W3169056896 cites W2092363477 @default.
• W3169056896 cites W2093413416 @default.
• W3169056896 cites W2125930376 @default.
• W3169056896 cites W2138526118 @default.
• W3169056896 cites W2141342904 @default.
• W3169056896 cites W2160128879 @default.
• W3169056896 cites W2202743880 @default.
• W3169056896 cites W2555297663 @default.
• W3169056896 cites W2586749826 @default.
• W3169056896 cites W2762489844 @default.
• W3169056896 cites W2793547099 @default.
• W3169056896 cites W2800555693 @default.
• W3169056896 cites W2886363262 @default.
• W3169056896 cites W2897820616 @default.
• W3169056896 cites W2901827656 @default.
• W3169056896 cites W2942835542 @default.
• W3169056896 cites W2996057353 @default.
• W3169056896 cites W3090962484 @default.
• W3169056896 doi "https://doi.org/10.1186/s13075-021-02528-5" @default.
• W3169056896 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8182933" @default.
• W3169056896 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34092252" @default.
• W3169056896 hasPublicationYear "2021" @default.
• W3169056896 type Work @default.
• W3169056896 sameAs 3169056896 @default.
• W3169056896 citedByCount "12" @default.
• W3169056896 countsByYear W31690568962021 @default.
• W3169056896 countsByYear W31690568962022 @default.
• W3169056896 countsByYear W31690568962023 @default.
• W3169056896 crossrefType "journal-article" @default.
• W3169056896 hasAuthorship W3169056896A5011051142 @default.
• W3169056896 hasAuthorship W3169056896A5011886992 @default.
• W3169056896 hasAuthorship W3169056896A5017259150 @default.
• W3169056896 hasAuthorship W3169056896A5033020983 @default.
• W3169056896 hasAuthorship W3169056896A5040063597 @default.
• W3169056896 hasAuthorship W3169056896A5045733957 @default.
• W3169056896 hasAuthorship W3169056896A5057205976 @default.
• W3169056896 hasAuthorship W3169056896A5077400124 @default.
• W3169056896 hasAuthorship W3169056896A5089817311 @default.
• W3169056896 hasBestOaLocation W31690568961 @default.
• W3169056896 hasConcept C126322002 @default.
• W3169056896 hasConcept C142724271 @default.
• W3169056896 hasConcept C159654299 @default.
• W3169056896 hasConcept C163764329 @default.
• W3169056896 hasConcept C198451711 @default.
• W3169056896 hasConcept C203014093 @default.
• W3169056896 hasConcept C2776301714 @default.
• W3169056896 hasConcept C2777077863 @default.
• W3169056896 hasConcept C2777468819 @default.
• W3169056896 hasConcept C2777575956 @default.
• W3169056896 hasConcept C2779129087 @default.
• W3169056896 hasConcept C2780648854 @default.
• W3169056896 hasConcept C2781069245 @default.
• W3169056896 hasConcept C48632299 @default.
• W3169056896 hasConcept C504460877 @default.
• W3169056896 hasConcept C515207424 @default.
• W3169056896 hasConcept C55493867 @default.
• W3169056896 hasConcept C71924100 @default.
• W3169056896 hasConcept C86803240 @default.
• W3169056896 hasConceptScore W3169056896C126322002 @default.
• W3169056896 hasConceptScore W3169056896C142724271 @default.
• W3169056896 hasConceptScore W3169056896C159654299 @default.
• W3169056896 hasConceptScore W3169056896C163764329 @default.
• W3169056896 hasConceptScore W3169056896C198451711 @default.
• W3169056896 hasConceptScore W3169056896C203014093 @default.
• W3169056896 hasConceptScore W3169056896C2776301714 @default.
• W3169056896 hasConceptScore W3169056896C2777077863 @default.
• W3169056896 hasConceptScore W3169056896C2777468819 @default.
• W3169056896 hasConceptScore W3169056896C2777575956 @default.
• W3169056896 hasConceptScore W3169056896C2779129087 @default.
• W3169056896 hasConceptScore W3169056896C2780648854 @default.
• W3169056896 hasConceptScore W3169056896C2781069245 @default.
• W3169056896 hasConceptScore W3169056896C48632299 @default.
• W3169056896 hasConceptScore W3169056896C504460877 @default.
• W3169056896 hasConceptScore W3169056896C515207424 @default.
• W3169056896 hasConceptScore W3169056896C55493867 @default.
• W3169056896 hasConceptScore W3169056896C71924100 @default.
• W3169056896 hasConceptScore W3169056896C86803240 @default.
• W3169056896 hasFunder F4320309559 @default.
• W3169056896 hasFunder F4320337355 @default.
• W3169056896 hasFunder F4320337362 @default.
• W3169056896 hasFunder F4320337472 @default.

• next