Matches in SemOpenAlex for { <https://semopenalex.org/work/W3169067063> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W3169067063 abstract "Liver sinusoids are lined by a fenestrated endothelium that lacks a basement membrane (BM). Production of sinusoidal BM along with loss of fenestrae characterizes capillarization of sinusoids that is a significant pathology accompanying advanced fibrotic changes. Liver fibrosis is prevalent in elderly cadavers; however, BM formation in these liver samples has yet to be studied. Collagen type IV (col IV) and laminin are major BM proteins and their co-distribution around sinusoids provides an immunohistochemical marker of BM formation. Here we examined sites of sinusoidal BM formation in elderly cadaveric livers with advanced septal fibrosis. We found co-distribution of col IV and laminin in BM of bile ducts and blood vessels in portal tracts, providing a positive control. However, the thickened walls of fibrotic central veins were positive for col IV but not for laminin. Within the lobules, Col IV immunostaining of the sinusoidal lining appeared continuous and was panlobular. In contrast, laminin staining was patchy, occurring commonly in sinusoids close to fibrotic portal tracts and septa, less commonly in mid-lobular and rarely in centrilobular areas. Consecutive sections revealed that laminin co-distributed with col IV in these sinusoidal locations, thus marking the sites of perisinusoidal BM formation in the elderly fibrotic liver, possibly in association with the capillarization of sinusoids." @default.
- W3169067063 created "2021-06-22" @default.
- W3169067063 creator A5001777927 @default.
- W3169067063 creator A5012690530 @default.
- W3169067063 creator A5037219238 @default.
- W3169067063 date "2013-04-01" @default.
- W3169067063 modified "2023-09-23" @default.
- W3169067063 title "Co‐distribution of Collagen Type IV and Laminin Around Sinusoids in Liver Fibrosis of Elderly Cadavers: Immunohistochemical Marker of Perisinusoidal Basement Membrane Formation" @default.
- W3169067063 doi "https://doi.org/10.1096/fasebj.27.1_supplement.523.13" @default.
- W3169067063 hasPublicationYear "2013" @default.
- W3169067063 type Work @default.
- W3169067063 sameAs 3169067063 @default.
- W3169067063 citedByCount "0" @default.
- W3169067063 crossrefType "journal-article" @default.
- W3169067063 hasAuthorship W3169067063A5001777927 @default.
- W3169067063 hasAuthorship W3169067063A5012690530 @default.
- W3169067063 hasAuthorship W3169067063A5037219238 @default.
- W3169067063 hasConcept C105702510 @default.
- W3169067063 hasConcept C142724271 @default.
- W3169067063 hasConcept C189165786 @default.
- W3169067063 hasConcept C202751555 @default.
- W3169067063 hasConcept C204232928 @default.
- W3169067063 hasConcept C2776193487 @default.
- W3169067063 hasConcept C2776200302 @default.
- W3169067063 hasConcept C2776417487 @default.
- W3169067063 hasConcept C2777107211 @default.
- W3169067063 hasConcept C2779814568 @default.
- W3169067063 hasConcept C2780559512 @default.
- W3169067063 hasConcept C2993667909 @default.
- W3169067063 hasConcept C4224716 @default.
- W3169067063 hasConcept C55450435 @default.
- W3169067063 hasConcept C55493867 @default.
- W3169067063 hasConcept C71924100 @default.
- W3169067063 hasConcept C86803240 @default.
- W3169067063 hasConcept C95444343 @default.
- W3169067063 hasConceptScore W3169067063C105702510 @default.
- W3169067063 hasConceptScore W3169067063C142724271 @default.
- W3169067063 hasConceptScore W3169067063C189165786 @default.
- W3169067063 hasConceptScore W3169067063C202751555 @default.
- W3169067063 hasConceptScore W3169067063C204232928 @default.
- W3169067063 hasConceptScore W3169067063C2776193487 @default.
- W3169067063 hasConceptScore W3169067063C2776200302 @default.
- W3169067063 hasConceptScore W3169067063C2776417487 @default.
- W3169067063 hasConceptScore W3169067063C2777107211 @default.
- W3169067063 hasConceptScore W3169067063C2779814568 @default.
- W3169067063 hasConceptScore W3169067063C2780559512 @default.
- W3169067063 hasConceptScore W3169067063C2993667909 @default.
- W3169067063 hasConceptScore W3169067063C4224716 @default.
- W3169067063 hasConceptScore W3169067063C55450435 @default.
- W3169067063 hasConceptScore W3169067063C55493867 @default.
- W3169067063 hasConceptScore W3169067063C71924100 @default.
- W3169067063 hasConceptScore W3169067063C86803240 @default.
- W3169067063 hasConceptScore W3169067063C95444343 @default.
- W3169067063 hasIssue "S1" @default.
- W3169067063 hasLocation W31690670631 @default.
- W3169067063 hasOpenAccess W3169067063 @default.
- W3169067063 hasPrimaryLocation W31690670631 @default.
- W3169067063 hasRelatedWork W1831527112 @default.
- W3169067063 hasRelatedWork W2013736587 @default.
- W3169067063 hasRelatedWork W2106125634 @default.
- W3169067063 hasRelatedWork W2320970657 @default.
- W3169067063 hasRelatedWork W2396199971 @default.
- W3169067063 hasRelatedWork W2418764233 @default.
- W3169067063 hasRelatedWork W2913716258 @default.
- W3169067063 hasRelatedWork W3016634352 @default.
- W3169067063 hasRelatedWork W3169067063 @default.
- W3169067063 hasRelatedWork W75623825 @default.
- W3169067063 hasVolume "27" @default.
- W3169067063 isParatext "false" @default.
- W3169067063 isRetracted "false" @default.
- W3169067063 magId "3169067063" @default.
- W3169067063 workType "article" @default.