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- W3169132395 endingPage "117" @default.
- W3169132395 startingPage "105" @default.
- W3169132395 abstract "Organoids are a novel three-dimensional stem cells' culture system that allows the in vitro recapitulation of organs/tissues structure complexity. Pluripotent and adult stem cells are included in a peculiar microenvironment consisting of a supporting structure (an extracellular matrix (ECM)-like component) and a cocktail of soluble bioactive molecules that, together, mimic the stem cell niche organization. It is noteworthy that the balance of all microenvironmental components is the most critical step for obtaining the successful development of an accurate organoid instead of an organoid with heterogeneous morphology, size, and cellular composition. Within this system, mechanical forces exerted on stem cells are collected by cellular proteins and transduced via mechanosensing-mechanotransduction mechanisms in biochemical signaling that dictate the stem cell specification process toward the formation of organoids. This review discusses the role of the environment in organoids formation and focuses on the effect of physical components on the developmental system. The work starts with a biological description of organoids and continues with the relevance of physical forces in the organoid environment formation. In this context, the methods used to generate organoids and some relevant published reports are discussed as examples showing the key role of mechanosensing-mechanotransduction mechanisms in stem cell-derived organoids." @default.
- W3169132395 created "2021-06-22" @default.
- W3169132395 creator A5017383179 @default.
- W3169132395 creator A5039057663 @default.
- W3169132395 creator A5044906308 @default.
- W3169132395 creator A5088196352 @default.
- W3169132395 creator A5089481787 @default.
- W3169132395 date "2021-06-13" @default.
- W3169132395 modified "2023-10-16" @default.
- W3169132395 title "The role of physical cues in the development of stem cell-derived organoids" @default.
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