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- W3169151502 abstract "Heparan sulfate (HS) is an extraordinarily diverse type of glycosaminoglycan (GAG) that is ubiquitously expressed on the cell surface and in the extracellular matrix where it interacts with a multitude of growth factors and morphogens. The association of HS chains with the various protein partners, though seemingly promiscuous, is surprisingly unique, and is largely dictated by the spatiotemporal expression of various modifying enzymes. Playing a central role in a myriad of cellular and physiological processes, its involvement in regulating developmental decisions is under intense investigation. Stem cells are distinguished by their characteristics of self-renewal and pluripotency. Self-renewal allows stem cells to proliferate indefinitely in their undifferentiated/early differentiated state, whereas pluripotency implies their capacity to differentiate into different cell lineages. Recent studies have provided important information regarding the role of HS in regulating the self-renewal and differentiation capacity of both embryonic and adult stem cells. Here we review the current advances that have been made in understanding the function and related structural changes of HS during stem cell differentiation and in deciphering the underlying molecular mechanisms with a focus on embryonic stem cells (ESCs), neuronal progenitor cells (NPC), and prostate stem cells (PrSCs)." @default.
- W3169151502 created "2021-06-22" @default.
- W3169151502 creator A5061125875 @default.
- W3169151502 creator A5081163835 @default.
- W3169151502 date "2021-01-01" @default.
- W3169151502 modified "2023-09-27" @default.
- W3169151502 title "Regulatory Functions of Heparan Sulfate in Stem Cell Self-Renewal and Differentiation" @default.
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- W3169151502 doi "https://doi.org/10.1007/978-3-030-73453-4_5" @default.
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