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- W3169173887 abstract "Aldehydes, ketones, and carboxylic acids are important intermediates and end products of many metabolic processes. In this study, the use of 2-hydrazinoquinoline (2-HQ) as a novel derivatization agent for LC-MS analysis of aldehydes, ketones, and carboxylic acids in biological samples was explored, and the conditions for the derivatization reaction were optimized. The formation of carboxylic acid derivatives is attributed to the esterification reaction between 2-HQ and carboxyl group, while the production of aldehyde and ketone derivatives is through the formation of Schiff bases between 2-HQ and carbonyl group. Using this 2-HQ-based approach, the metabolic disorder induced by streptozotocin-elicited diabetes was examined by the LC-MS-based metabolomics. The results showed the time-dependent separation of mouse urine samples from STZ treatment in a multivariate model of urinary metabolites. Both known and novel small-molecule biomarkers associated with STZ-induced ketoacidosis were conveniently identified and subsequently elucidated, reflecting the dramatic changes in nutrient (glucose, amino acid, and lipid) and energy metabolism after STZ treatment." @default.
- W3169173887 created "2021-06-22" @default.
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- W3169173887 date "2013-04-01" @default.
- W3169173887 modified "2023-09-23" @default.
- W3169173887 title "2‐Hydrazinoquinoline as a novel derivatization agent for LC‐MS‐Based metabolomic investigation of streptozotocin‐elicited ketoacidosis" @default.
- W3169173887 doi "https://doi.org/10.1096/fasebj.27.1_supplement.1073.3" @default.
- W3169173887 hasPublicationYear "2013" @default.
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