FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3169185629> ?p ?o ?g. }

• W3169185629 abstract "Abstract Background and Aims Monoclonal gammopathies of uncertain significance (MGUS) are very prevalent, but neoplastic transformation barely reaches 1% per year. Renal involvement in the course of a MGUS is a risk factor for complications. The objective of our study is to determine the prognosis of MGUS that present renal deterioration during their evolution. Method In the present retrospective cohort study, MGUS cases from our center were included. Baseline epidemiological and comorbidity data were collected (including renal function and hematological parameters). At 6 and 12 months, data on renal function and proteinuria were collected. During the follow-up, fatal events and the need for renal replacement therapy (RRT) were recorded as a combined endopoint. Associated factors to this combined endpoint were evaluated. Results One hundred twenty patients (47% women, age 81±9 years.) with diagnosis of MGUS were included. Of these, 61 (51%) had renal involvement at the time of diagnosis and 16 (13%) had an estimated glomerular filtration rate (eGFR) of less than 60 ml/min/1.73m2 during follow up. Associated factors with presenting eGFR less than 60 ml/min/1.73m2 were hypertension (p=0.001), peripheral vascular disease (p=0.05), age (p=0.05), Charlson comorbidity index (p&lt;0.001), β2microglobulin (p = 0.002), baseline proteinuria (p &lt;0.001) and baseline renal function (p &lt;0.001). During follow-up (median 41 [20-60] months), 34 patients (28%) presented the combined event (8 required RRT and 28 died). The presence of an eGFR less than 60 ml /min/1.73m2 during the first year of follow-up was associated with the combined event (p = 0.028) (Figure 1). In a multivariate model adjusted for age, sex and baseline CKD, the presence of a determination of eGFR lower than 60 ml/min/1.73m2 was an independent predictor for the combined event (HR 3.9 [95% CI 1.4-11.3], p = 0.009). In patients without chronic kidney disease at baseline, 13 (22%) combined events were reported. The incidence of a determination of eGFR lower than 60 ml/min/1.73m2 was associated with the combined event during follow-up (p = 0.012). In a multivariate model adjusted for age and Charlson index, presenting an eGFR lower than 60 ml/min/1.73m2 was an independent predictor for the combined event (HR 6.7 [95% CI 1.7-26.7], p = 0.007) (Figure 2) Conclusion Among patients with MGUS, the presence of eGFR lower than 60 ml/min/1.73m2 is independently associated with a higher incidence of RRT and/or mortality." @default.
• W3169185629 created "2021-06-22" @default.
• W3169185629 creator A5005031266 @default.
• W3169185629 creator A5006165967 @default.
• W3169185629 creator A5021639874 @default.
• W3169185629 creator A5054746886 @default.
• W3169185629 creator A5086624874 @default.
• W3169185629 date "2021-05-01" @default.
• W3169185629 modified "2023-09-26" @default.
• W3169185629 title "MO198IMPACT OF KIDNEY FUNCTION ON THE EVOLUTION OF MONOCLONAL GAMMOPATHIES OF UNCERTAIN SIGNIFICANCE" @default.
• W3169185629 doi "https://doi.org/10.1093/ndt/gfab092.0076" @default.
• W3169185629 hasPublicationYear "2021" @default.
• W3169185629 type Work @default.
• W3169185629 sameAs 3169185629 @default.
• W3169185629 citedByCount "0" @default.
• W3169185629 crossrefType "journal-article" @default.
• W3169185629 hasAuthorship W3169185629A5005031266 @default.
• W3169185629 hasAuthorship W3169185629A5006165967 @default.
• W3169185629 hasAuthorship W3169185629A5021639874 @default.
• W3169185629 hasAuthorship W3169185629A5054746886 @default.
• W3169185629 hasAuthorship W3169185629A5086624874 @default.
• W3169185629 hasBestOaLocation W31691856291 @default.
• W3169185629 hasConcept C107130276 @default.
• W3169185629 hasConcept C126322002 @default.
• W3169185629 hasConcept C126894567 @default.
• W3169185629 hasConcept C159641895 @default.
• W3169185629 hasConcept C159654299 @default.
• W3169185629 hasConcept C163864487 @default.
• W3169185629 hasConcept C167135981 @default.
• W3169185629 hasConcept C203014093 @default.
• W3169185629 hasConcept C2777250017 @default.
• W3169185629 hasConcept C2778653478 @default.
• W3169185629 hasConcept C2779159551 @default.
• W3169185629 hasConcept C2779541074 @default.
• W3169185629 hasConcept C2779561371 @default.
• W3169185629 hasConcept C2780091579 @default.
• W3169185629 hasConcept C542903549 @default.
• W3169185629 hasConcept C71924100 @default.
• W3169185629 hasConcept C72563966 @default.
• W3169185629 hasConcept C90924648 @default.
• W3169185629 hasConceptScore W3169185629C107130276 @default.
• W3169185629 hasConceptScore W3169185629C126322002 @default.
• W3169185629 hasConceptScore W3169185629C126894567 @default.
• W3169185629 hasConceptScore W3169185629C159641895 @default.
• W3169185629 hasConceptScore W3169185629C159654299 @default.
• W3169185629 hasConceptScore W3169185629C163864487 @default.
• W3169185629 hasConceptScore W3169185629C167135981 @default.
• W3169185629 hasConceptScore W3169185629C203014093 @default.
• W3169185629 hasConceptScore W3169185629C2777250017 @default.
• W3169185629 hasConceptScore W3169185629C2778653478 @default.
• W3169185629 hasConceptScore W3169185629C2779159551 @default.
• W3169185629 hasConceptScore W3169185629C2779541074 @default.
• W3169185629 hasConceptScore W3169185629C2779561371 @default.
• W3169185629 hasConceptScore W3169185629C2780091579 @default.
• W3169185629 hasConceptScore W3169185629C542903549 @default.
• W3169185629 hasConceptScore W3169185629C71924100 @default.
• W3169185629 hasConceptScore W3169185629C72563966 @default.
• W3169185629 hasConceptScore W3169185629C90924648 @default.
• W3169185629 hasIssue "Supplement_1" @default.
• W3169185629 hasLocation W31691856291 @default.
• W3169185629 hasOpenAccess W3169185629 @default.
• W3169185629 hasPrimaryLocation W31691856291 @default.
• W3169185629 hasRelatedWork W11766017 @default.
• W3169185629 hasRelatedWork W13531969 @default.
• W3169185629 hasRelatedWork W15740813 @default.
• W3169185629 hasRelatedWork W16336872 @default.
• W3169185629 hasRelatedWork W16539384 @default.
• W3169185629 hasRelatedWork W20207445 @default.
• W3169185629 hasRelatedWork W21609466 @default.
• W3169185629 hasRelatedWork W2890379 @default.
• W3169185629 hasRelatedWork W7977891 @default.
• W3169185629 hasRelatedWork W21794515 @default.
• W3169185629 hasVolume "36" @default.
• W3169185629 isParatext "false" @default.
• W3169185629 isRetracted "false" @default.
• W3169185629 magId "3169185629" @default.
• W3169185629 workType "article" @default.