Matches in SemOpenAlex for { <https://semopenalex.org/work/W3169202351> ?p ?o ?g. }
- W3169202351 endingPage "102032" @default.
- W3169202351 startingPage "102032" @default.
- W3169202351 abstract "Cellular growth arrest, associated with ‘senescence’, helps to safeguard against the accumulation of DNA damage which is often recognized as the underlying mechanism of a wide variety of age-related pathologies including cancer. Cellular senescence has also been described as a ‘double-edged sword’. In cancer, for example, the creation of an immune-suppressive milieu by senescent tumor cells through the senescence-associated secretory phenotype contributes toward carcinogenesis and cancer progression. The potential for cellular senescence to confer multi-faceted effects on tissue fate has led to a rejuvenated interest in its landscape and targeting. Interestingly, redox pathways have been described as both triggers and propagators of cellular senescence, leading to intricate cross-links between both pathways. In this review, we describe the mechanisms driving cellular senescence, the interface with cellular redox metabolism as well as the role that chemotherapy-induced senescence plays in secondary carcinogenesis. Notably, the role that anti-apoptotic proteins of the Bcl-2 family play in inducing drug resistance via mechanisms that involve senescence induction. Though the therapeutic targeting of senescent cells as cancer therapy remains in its infancy, we summarize the current development of senotherapeutics, including recognized senotherapies, as well as the repurposing of drugs as senomorphic/senolytic candidates." @default.
- W3169202351 created "2021-06-22" @default.
- W3169202351 creator A5014749788 @default.
- W3169202351 creator A5063159222 @default.
- W3169202351 creator A5063755644 @default.
- W3169202351 creator A5066867711 @default.
- W3169202351 creator A5079539757 @default.
- W3169202351 creator A5084717567 @default.
- W3169202351 date "2021-09-01" @default.
- W3169202351 modified "2023-10-01" @default.
- W3169202351 title "The redox-senescence axis and its therapeutic targeting" @default.
- W3169202351 cites W1033197108 @default.
- W3169202351 cites W1599464745 @default.
- W3169202351 cites W1647232018 @default.
- W3169202351 cites W1686601736 @default.
- W3169202351 cites W1752614770 @default.
- W3169202351 cites W1800944583 @default.
- W3169202351 cites W1829914012 @default.
- W3169202351 cites W1910950086 @default.
- W3169202351 cites W1932046626 @default.
- W3169202351 cites W1965037168 @default.
- W3169202351 cites W1965747780 @default.
- W3169202351 cites W1965797097 @default.
- W3169202351 cites W1970891016 @default.
- W3169202351 cites W1972320300 @default.
- W3169202351 cites W1976248697 @default.
- W3169202351 cites W1976635482 @default.
- W3169202351 cites W1977362098 @default.
- W3169202351 cites W1978174791 @default.
- W3169202351 cites W1980674137 @default.
- W3169202351 cites W1983673827 @default.
- W3169202351 cites W1983751803 @default.
- W3169202351 cites W1986221769 @default.
- W3169202351 cites W1991267681 @default.
- W3169202351 cites W1998663807 @default.
- W3169202351 cites W1998767677 @default.
- W3169202351 cites W2001353514 @default.
- W3169202351 cites W2004273407 @default.
- W3169202351 cites W2004314923 @default.
- W3169202351 cites W2007460671 @default.
- W3169202351 cites W2010417927 @default.
- W3169202351 cites W2013287222 @default.
- W3169202351 cites W2016244372 @default.
- W3169202351 cites W2016599680 @default.
- W3169202351 cites W2018365251 @default.
- W3169202351 cites W2019906376 @default.
- W3169202351 cites W2025290835 @default.
- W3169202351 cites W2026982091 @default.
- W3169202351 cites W2028169108 @default.
- W3169202351 cites W2030422492 @default.
- W3169202351 cites W2030795773 @default.
- W3169202351 cites W2032603938 @default.
- W3169202351 cites W2032874780 @default.
- W3169202351 cites W2033007699 @default.
- W3169202351 cites W2036079438 @default.
- W3169202351 cites W2037869103 @default.
- W3169202351 cites W2041535798 @default.
- W3169202351 cites W2043930391 @default.
- W3169202351 cites W2044496307 @default.
- W3169202351 cites W2052864717 @default.
- W3169202351 cites W2056161011 @default.
- W3169202351 cites W2057951424 @default.
- W3169202351 cites W2058849284 @default.
- W3169202351 cites W2061619522 @default.
- W3169202351 cites W2064262706 @default.
- W3169202351 cites W2067117191 @default.
- W3169202351 cites W2069519394 @default.
- W3169202351 cites W2070061120 @default.
- W3169202351 cites W2075614768 @default.
- W3169202351 cites W2077704747 @default.
- W3169202351 cites W2078956209 @default.
- W3169202351 cites W2085498425 @default.
- W3169202351 cites W2085683078 @default.
- W3169202351 cites W2087404852 @default.
- W3169202351 cites W2089218510 @default.
- W3169202351 cites W2090067193 @default.
- W3169202351 cites W2091369486 @default.
- W3169202351 cites W2091520939 @default.
- W3169202351 cites W2094992173 @default.
- W3169202351 cites W2095236624 @default.
- W3169202351 cites W2098873966 @default.
- W3169202351 cites W2098995242 @default.
- W3169202351 cites W2100550784 @default.
- W3169202351 cites W2104397341 @default.
- W3169202351 cites W2109838416 @default.
- W3169202351 cites W2110525250 @default.
- W3169202351 cites W2110761051 @default.
- W3169202351 cites W2115852450 @default.
- W3169202351 cites W2116054786 @default.
- W3169202351 cites W2128807350 @default.
- W3169202351 cites W2131078803 @default.
- W3169202351 cites W2133468132 @default.
- W3169202351 cites W2136380412 @default.
- W3169202351 cites W2138277729 @default.
- W3169202351 cites W2140204893 @default.
- W3169202351 cites W2140930678 @default.
- W3169202351 cites W2147030667 @default.
- W3169202351 cites W2150569822 @default.