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- W3169323702 startingPage "e1009073" @default.
- W3169323702 abstract "Neurons rely on localized mitochondria to fulfill spatially heterogeneous metabolic demands. Mitochondrial aging occurs on timescales shorter than the neuronal lifespan, necessitating transport of fresh material from the soma. Maintaining an optimal distribution of healthy mitochondria requires an interplay between a stationary pool localized to sites of high metabolic demand and a motile pool capable of delivering new material. Interchange between these pools can occur via transient fusion / fission events or by halting and restarting entire mitochondria. Our quantitative model of neuronal mitostasis identifies key parameters that govern steady-state mitochondrial health at discrete locations. Very infrequent exchange between stationary and motile pools optimizes this system. Exchange via transient fusion allows for robust maintenance, which can be further improved by selective recycling through mitophagy. These results provide a framework for quantifying how perturbations in organelle transport and interactions affect mitochondrial homeostasis in neurons, a key aspect underlying many neurodegenerative disorders." @default.
- W3169323702 created "2021-06-22" @default.
- W3169323702 creator A5027746139 @default.
- W3169323702 creator A5057051690 @default.
- W3169323702 date "2021-06-09" @default.
- W3169323702 modified "2023-10-18" @default.
- W3169323702 title "Optimizing mitochondrial maintenance in extended neuronal projections" @default.
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- W3169323702 doi "https://doi.org/10.1371/journal.pcbi.1009073" @default.
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