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- W3169348508 abstract "I read with great interest the cohort study by Galipeau et al1 entitled “Novel fecal biomarkers that precede clinical diagnosis of ulcerative colitis,” recently published in Gastroenterology, which found increased fecal proteolytic activity preceding the clinical diagnosis of ulcerative colitis along with changes in gut microbiota. I take a special interest in their article because I have suspected for a long time that increased proteases in feces may be the primary root cause of inflammatory bowel disease (IBD); I first proposed this idea in 2002,2 followed by a series of publications including a unified hypothesis published in 2012 on the etiology of IBD including the cause and mechanism of IBD and the relationship between ulcerative colitis and Crohn disease.3 However, I believe the increased activity of proteases associated with IBD is primarily the result of the impaired inactivation of pancreatic proteases, likely mediated by deconjugated bilirubin, because..." @default.
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- W3169348508 date "2021-06-14" @default.
- W3169348508 modified "2023-09-25" @default.
- W3169348508 title "High Fecal Proteolytic Activity That Precedes Ulcerative Colitis Likely Results From Impaired Inactivation of Pancreatic Proteases Rather Than Bacteria" @default.
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- W3169348508 doi "https://doi.org/10.1093/ibd/izab142" @default.
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