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- W3169361567 abstract "Non-lamellar lyotropic liquid crystalline (LLC) lipid nanoparticles contain internal multidimensional nanostructures such as the inverse bicontinuous cubic and the inverse hexagonal mesophases, which can respond to external stimuli and have the potential of controlling drug release. To date, the internal LLC mesophase responsiveness of these lipid nanoparticles is largely achieved by adding ionizable small molecules to the parent lipid such as monoolein (MO), the mixture of which is then dispersed into nanoparticle suspensions by commercially available poly(ethylene oxide)–poly(propylene oxide) block copolymers. In this study, the Reversible Addition-Fragmentation chain Transfer (RAFT) technique was used to synthesize a series of novel amphiphilic block copolymers (ABCs) containing a hydrophilic poly(ethylene glycol) (PEG) block, a hydrophobic block and one or two responsive blocks, i.e., poly(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acrylate) (PTBA) and/or poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA). High throughput small angle X-ray scattering studies demonstrated that the synthesized ABCs could simultaneously stabilize a range of LLC MO nanoparticles (vesicles, cubosomes, hexosomes, inverse micelles) and provide internal particle nanostructure responsiveness to changes of hydrogen peroxide (H2O2) concentrations, pH and temperature. It was found that the novel functional ABCs can substitute for the commercial polymer stabilizer and the ionizable additive in the formation of next generation non-lamellar lipid nanoparticles. These novel formulations have the potential to control drug release in the tumor microenvironment with endogenous H2O2 and acidic pH conditions." @default.
- W3169361567 created "2021-06-22" @default.
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- W3169361567 date "2021-06-15" @default.
- W3169361567 modified "2023-09-23" @default.
- W3169361567 title "Novel Amphiphilic Block Copolymers for the Formation of Stimuli-Responsive Non-Lamellar Lipid Nanoparticles" @default.
- W3169361567 cites W176735604 @default.
- W3169361567 cites W1963752211 @default.
- W3169361567 cites W1965561222 @default.
- W3169361567 cites W1976084169 @default.
- W3169361567 cites W1976415753 @default.
- W3169361567 cites W1977819127 @default.
- W3169361567 cites W1980956987 @default.
- W3169361567 cites W1984233008 @default.
- W3169361567 cites W1988394046 @default.
- W3169361567 cites W1989975668 @default.
- W3169361567 cites W1993422337 @default.
- W3169361567 cites W1995676656 @default.
- W3169361567 cites W1996179790 @default.
- W3169361567 cites W1999698653 @default.
- W3169361567 cites W2000966264 @default.
- W3169361567 cites W2002846858 @default.
- W3169361567 cites W2007263263 @default.
- W3169361567 cites W2010771888 @default.
- W3169361567 cites W2016995674 @default.
- W3169361567 cites W2018784408 @default.
- W3169361567 cites W2034011432 @default.
- W3169361567 cites W2035152323 @default.
- W3169361567 cites W2037608127 @default.
- W3169361567 cites W2044008423 @default.
- W3169361567 cites W2069488861 @default.
- W3169361567 cites W2078722368 @default.
- W3169361567 cites W2079426132 @default.
- W3169361567 cites W2157990526 @default.
- W3169361567 cites W2181631481 @default.
- W3169361567 cites W2267902799 @default.
- W3169361567 cites W2268449902 @default.
- W3169361567 cites W2304528392 @default.
- W3169361567 cites W2314114901 @default.
- W3169361567 cites W2315473884 @default.
- W3169361567 cites W2319450855 @default.
- W3169361567 cites W2332307725 @default.
- W3169361567 cites W2333506360 @default.
- W3169361567 cites W2335377235 @default.
- W3169361567 cites W2409548813 @default.
- W3169361567 cites W2518085003 @default.
- W3169361567 cites W2536289455 @default.
- W3169361567 cites W2562793266 @default.
- W3169361567 cites W2564544504 @default.
- W3169361567 cites W2576693146 @default.
- W3169361567 cites W2594539488 @default.
- W3169361567 cites W2595539542 @default.
- W3169361567 cites W2780159316 @default.
- W3169361567 cites W2785595475 @default.
- W3169361567 cites W2808722599 @default.
- W3169361567 cites W2810385438 @default.
- W3169361567 cites W281489398 @default.
- W3169361567 cites W2943987854 @default.
- W3169361567 cites W2952982703 @default.
- W3169361567 cites W2967990981 @default.
- W3169361567 cites W2969684055 @default.
- W3169361567 cites W2981917056 @default.
- W3169361567 cites W2998570436 @default.
- W3169361567 cites W2998919112 @default.
- W3169361567 cites W3000615389 @default.
- W3169361567 cites W3011996440 @default.
- W3169361567 cites W3015595954 @default.
- W3169361567 cites W3016944304 @default.
- W3169361567 cites W3022585610 @default.
- W3169361567 cites W3024703937 @default.
- W3169361567 cites W3027654830 @default.
- W3169361567 cites W3043621420 @default.
- W3169361567 cites W3046167497 @default.
- W3169361567 cites W3082209696 @default.
- W3169361567 cites W3113751899 @default.
- W3169361567 cites W3119327319 @default.
- W3169361567 cites W3131122759 @default.
- W3169361567 cites W3134251993 @default.
- W3169361567 cites W3142659727 @default.
- W3169361567 cites W3158315702 @default.
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- W3169361567 doi "https://doi.org/10.3390/molecules26123648" @default.
- W3169361567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8232580" @default.
- W3169361567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34203820" @default.
- W3169361567 hasPublicationYear "2021" @default.
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