FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3169432079> ?p ?o ?g. }

• W3169432079 endingPage "705" @default.
• W3169432079 startingPage "696" @default.
• W3169432079 abstract "This study aimed to clarify the mechanism of propofol on proliferation and apoptosis of colorectal cancer (CRC) cell. SW620 and HCT15 cells were exposed to different concentrations of propofol, the proliferation and apoptotic rate, were measured by MTT, colony formation and flow cytometry assays, respectively. The expressions of miR-1-3p and insulin-like growth factors 1 (IGF1) were examined by real-time polymerase chain reaction (RT-qPCR). Western bolt was employed to quantify the protein levels of IGF1 and apoptotic proteins. The molecular interaction between miR-1-3p and IGF1 was validated using dual-luciferase reporter assay. A xenograft tumor model was established to further assess the effects of propofol on CRC in vivo. Propofol dramatically decreased the proliferation and elevated apoptotic rate of CRC cells. RT-qPCR assay demonstrated that miR-1-3p was downregulated in CRC cells, and could be strikingly increased by propofol. Importantly, miR-1-3p inhibited IGF-1 expression through interacting with its 3'-UTR region, thus inactivating AKT/mTOR signals. Gain or loss of functional study revealed that miR-1-3p downregulation remarkedly diminished the anti-tumor roles of propofol by directly inhibiting IGF1. In vivo study showed that propofol inhibited tumor growth by regulating miR-1-3p/IGF1 axis. Our data eventually elucidated that propofol suppressed CRC progression by promoting miR-1-3p which targeted IGF1. These results might provide a scientific basis for the application of propofol on the clinical surgery and the prognosis of patients with CRC." @default.
• W3169432079 created "2021-06-22" @default.
• W3169432079 creator A5006966476 @default.
• W3169432079 creator A5032613807 @default.
• W3169432079 creator A5056704170 @default.
• W3169432079 creator A5064391166 @default.
• W3169432079 date "2021-06-14" @default.
• W3169432079 modified "2023-09-27" @default.
• W3169432079 title "Propofol regulates miR-1-3p/IGF1 axis to inhibit the proliferation and accelerates apoptosis of colorectal cancer cells" @default.
• W3169432079 cites W1835635809 @default.
• W3169432079 cites W1896050588 @default.
• W3169432079 cites W1967422586 @default.
• W3169432079 cites W1973174717 @default.
• W3169432079 cites W1982819321 @default.
• W3169432079 cites W2004690081 @default.
• W3169432079 cites W2032665873 @default.
• W3169432079 cites W2049338354 @default.
• W3169432079 cites W2058140056 @default.
• W3169432079 cites W2075410690 @default.
• W3169432079 cites W2083985770 @default.
• W3169432079 cites W2088716825 @default.
• W3169432079 cites W2129168946 @default.
• W3169432079 cites W2132249975 @default.
• W3169432079 cites W2159732031 @default.
• W3169432079 cites W2170859351 @default.
• W3169432079 cites W2535555359 @default.
• W3169432079 cites W2740662413 @default.
• W3169432079 cites W2789361911 @default.
• W3169432079 cites W2790858752 @default.
• W3169432079 cites W2791187461 @default.
• W3169432079 cites W2883039719 @default.
• W3169432079 cites W2888863350 @default.
• W3169432079 cites W2889645383 @default.
• W3169432079 cites W2921763806 @default.
• W3169432079 cites W2923287877 @default.
• W3169432079 cites W2925134875 @default.
• W3169432079 cites W2927309982 @default.
• W3169432079 cites W2940715928 @default.
• W3169432079 cites W2978966448 @default.
• W3169432079 cites W2981527751 @default.
• W3169432079 cites W2997305739 @default.
• W3169432079 cites W4211147392 @default.
• W3169432079 cites W632529473 @default.
• W3169432079 doi "https://doi.org/10.1093/toxres/tfab047" @default.
• W3169432079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8561266" @default.
• W3169432079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34745557" @default.
• W3169432079 hasPublicationYear "2021" @default.
• W3169432079 type Work @default.
• W3169432079 sameAs 3169432079 @default.
• W3169432079 citedByCount "6" @default.
• W3169432079 countsByYear W31694320792021 @default.
• W3169432079 countsByYear W31694320792022 @default.
• W3169432079 countsByYear W31694320792023 @default.
• W3169432079 crossrefType "journal-article" @default.
• W3169432079 hasAuthorship W3169432079A5006966476 @default.
• W3169432079 hasAuthorship W3169432079A5032613807 @default.
• W3169432079 hasAuthorship W3169432079A5056704170 @default.
• W3169432079 hasAuthorship W3169432079A5064391166 @default.
• W3169432079 hasBestOaLocation W31694320791 @default.
• W3169432079 hasConcept C104317684 @default.
• W3169432079 hasConcept C121608353 @default.
• W3169432079 hasConcept C126322002 @default.
• W3169432079 hasConcept C127561419 @default.
• W3169432079 hasConcept C185592680 @default.
• W3169432079 hasConcept C190283241 @default.
• W3169432079 hasConcept C203014093 @default.
• W3169432079 hasConcept C207001950 @default.
• W3169432079 hasConcept C2776277131 @default.
• W3169432079 hasConcept C2780783641 @default.
• W3169432079 hasConcept C502942594 @default.
• W3169432079 hasConcept C526805850 @default.
• W3169432079 hasConcept C54355233 @default.
• W3169432079 hasConcept C553184892 @default.
• W3169432079 hasConcept C55493867 @default.
• W3169432079 hasConcept C62112901 @default.
• W3169432079 hasConcept C71924100 @default.
• W3169432079 hasConcept C75217442 @default.
• W3169432079 hasConcept C86554907 @default.
• W3169432079 hasConcept C86803240 @default.
• W3169432079 hasConcept C98274493 @default.
• W3169432079 hasConceptScore W3169432079C104317684 @default.
• W3169432079 hasConceptScore W3169432079C121608353 @default.
• W3169432079 hasConceptScore W3169432079C126322002 @default.
• W3169432079 hasConceptScore W3169432079C127561419 @default.
• W3169432079 hasConceptScore W3169432079C185592680 @default.
• W3169432079 hasConceptScore W3169432079C190283241 @default.
• W3169432079 hasConceptScore W3169432079C203014093 @default.
• W3169432079 hasConceptScore W3169432079C207001950 @default.
• W3169432079 hasConceptScore W3169432079C2776277131 @default.
• W3169432079 hasConceptScore W3169432079C2780783641 @default.
• W3169432079 hasConceptScore W3169432079C502942594 @default.
• W3169432079 hasConceptScore W3169432079C526805850 @default.
• W3169432079 hasConceptScore W3169432079C54355233 @default.
• W3169432079 hasConceptScore W3169432079C553184892 @default.
• W3169432079 hasConceptScore W3169432079C55493867 @default.
• W3169432079 hasConceptScore W3169432079C62112901 @default.
• W3169432079 hasConceptScore W3169432079C71924100 @default.
• W3169432079 hasConceptScore W3169432079C75217442 @default.

• next