Matches in SemOpenAlex for { <https://semopenalex.org/work/W3169580211> ?p ?o ?g. }
- W3169580211 abstract "Plexin-B2 deletion leads to aberrant lamination of cerebellar granule neurons (CGNs) and Purkinje cells. Although in the cerebellum Plexin-B2 is only expressed by proliferating CGN precursors in the outer external granule layer (oEGL), its function in CGN development is still elusive. Here, we used 3D imaging, in vivo electroporation and live-imaging techniques to study CGN development in novel cerebellum-specific Plxnb2 conditional knockout mice. We show that proliferating CGNs in Plxnb2 mutants not only escape the oEGL and mix with newborn postmitotic CGNs. Furthermore, motility of mitotic precursors and early postmitotic CGNs is altered. Together, this leads to the formation of ectopic patches of CGNs at the cerebellar surface and an intermingling of normally time-stamped parallel fibers in the molecular layer (ML), and aberrant arborization of Purkinje cell dendrites. There results suggest that Plexin-B2 restricts CGN motility and might have a function in cytokinesis." @default.
- W3169580211 created "2021-06-22" @default.
- W3169580211 creator A5000877660 @default.
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- W3169580211 creator A5053496442 @default.
- W3169580211 creator A5067921141 @default.
- W3169580211 creator A5068489058 @default.
- W3169580211 date "2021-06-08" @default.
- W3169580211 modified "2023-10-06" @default.
- W3169580211 title "Plexin-B2 controls the timing of differentiation and the motility of cerebellar granule neurons" @default.
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