Matches in SemOpenAlex for { <https://semopenalex.org/work/W3169586328> ?p ?o ?g. }
- W3169586328 endingPage "35" @default.
- W3169586328 startingPage "31" @default.
- W3169586328 abstract "To retrospectively evaluate the effect of anti-tumor necrosis factor-alpha (TNF-α) drugs on hepatic and renal functions in patients with ankylosing spondylitis (AS).A total of 148 patients (89 male, 59 female) who were followed up for a minimum duration of 1 year on newly started anti TNF-α therapy were included. Patients were divided into 5 groups based on the TNF-α treatment received. Initially, pre-treatment BASDAI (Bath Ankylosing Spondylitis Disease Activity) scores and laboratory results were compared between the groups before the treatment. Also, ESR (erythrocyte sedimentation rate), C-reactive protein (CRP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, and creatinine values were compared before treatment and at 3, 6, and 12 months after treatment. Also presence of hematuria and proteinuria was examined.Of the overall group, 68 (45%), 33 (22%), 23 (15%), 18 (12%), and 6 (4%) received golimumab, certolizumab, etanercept, adalimumab, and infliximab. Baseline demographic characteristics, disease activity scores, and laboratory parameters were comparable between the groups (P > .05). There was a significant decline in BASDAI scores from baseline at 12 months (pre-treatment 5.24 ± 0.5, 3.01 ± 0.48 post-treatment at 12 months, P < .001). Although there was an increase in AST and ALT from baseline to 3, 6, and 12 months of treatment, the values remained within normal range (P > .05). Also, there were no significant changes in mean creatinine levels (P > .05). There were no correlations between disease activity parameters (ESR, CRP, and BASDAI) and hepatic and renal functions (P > .05).No hepatotoxicity or nephrotoxicity were found in association with the use of anti-TNF-α agents over a 1 year period. However, hepatotoxicity and nephrotoxicity are among known adverse effects of these agents. Based on the existing literature data, routine monitoring of patients in terms of potential hepatic and renal toxicity before and after treatment remains a valid recommendation in clinical practice." @default.
- W3169586328 created "2021-06-22" @default.
- W3169586328 creator A5012844496 @default.
- W3169586328 creator A5077432852 @default.
- W3169586328 date "2022-01-13" @default.
- W3169586328 modified "2023-10-18" @default.
- W3169586328 title "Influence of anti-TNF-α treatment on liver and kidney functions in patients with ankylosing spondylitis: A retrospective longitudinal study" @default.
- W3169586328 cites W114418843 @default.
- W3169586328 cites W1520542820 @default.
- W3169586328 cites W1973564016 @default.
- W3169586328 cites W1976378231 @default.
- W3169586328 cites W1978315096 @default.
- W3169586328 cites W1979445622 @default.
- W3169586328 cites W1990305566 @default.
- W3169586328 cites W1993743846 @default.
- W3169586328 cites W2002975895 @default.
- W3169586328 cites W2012487047 @default.
- W3169586328 cites W2020316032 @default.
- W3169586328 cites W2051154544 @default.
- W3169586328 cites W2076327259 @default.
- W3169586328 cites W2076651424 @default.
- W3169586328 cites W2092773063 @default.
- W3169586328 cites W2117291477 @default.
- W3169586328 cites W2117631121 @default.
- W3169586328 cites W2125346357 @default.
- W3169586328 cites W2127756765 @default.
- W3169586328 cites W2164313072 @default.
- W3169586328 cites W2169279953 @default.
- W3169586328 cites W2269562035 @default.
- W3169586328 cites W2572897530 @default.
- W3169586328 cites W2735952875 @default.
- W3169586328 cites W2968128868 @default.
- W3169586328 cites W2341212936 @default.
- W3169586328 doi "https://doi.org/10.5152/eurjrheum.2021.20230" @default.
- W3169586328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34101575" @default.
- W3169586328 hasPublicationYear "2022" @default.
- W3169586328 type Work @default.
- W3169586328 sameAs 3169586328 @default.
- W3169586328 citedByCount "0" @default.
- W3169586328 crossrefType "journal-article" @default.
- W3169586328 hasAuthorship W3169586328A5012844496 @default.
- W3169586328 hasAuthorship W3169586328A5077432852 @default.
- W3169586328 hasBestOaLocation W31695863281 @default.
- W3169586328 hasConcept C126322002 @default.
- W3169586328 hasConcept C159641895 @default.
- W3169586328 hasConcept C17991360 @default.
- W3169586328 hasConcept C2776260265 @default.
- W3169586328 hasConcept C2777077863 @default.
- W3169586328 hasConcept C2777138892 @default.
- W3169586328 hasConcept C2777226972 @default.
- W3169586328 hasConcept C2777402515 @default.
- W3169586328 hasConcept C2777453003 @default.
- W3169586328 hasConcept C2778143017 @default.
- W3169586328 hasConcept C2778606649 @default.
- W3169586328 hasConcept C2779561371 @default.
- W3169586328 hasConcept C2780091579 @default.
- W3169586328 hasConcept C2780132546 @default.
- W3169586328 hasConcept C2780306776 @default.
- W3169586328 hasConcept C2781290027 @default.
- W3169586328 hasConcept C71924100 @default.
- W3169586328 hasConcept C90924648 @default.
- W3169586328 hasConceptScore W3169586328C126322002 @default.
- W3169586328 hasConceptScore W3169586328C159641895 @default.
- W3169586328 hasConceptScore W3169586328C17991360 @default.
- W3169586328 hasConceptScore W3169586328C2776260265 @default.
- W3169586328 hasConceptScore W3169586328C2777077863 @default.
- W3169586328 hasConceptScore W3169586328C2777138892 @default.
- W3169586328 hasConceptScore W3169586328C2777226972 @default.
- W3169586328 hasConceptScore W3169586328C2777402515 @default.
- W3169586328 hasConceptScore W3169586328C2777453003 @default.
- W3169586328 hasConceptScore W3169586328C2778143017 @default.
- W3169586328 hasConceptScore W3169586328C2778606649 @default.
- W3169586328 hasConceptScore W3169586328C2779561371 @default.
- W3169586328 hasConceptScore W3169586328C2780091579 @default.
- W3169586328 hasConceptScore W3169586328C2780132546 @default.
- W3169586328 hasConceptScore W3169586328C2780306776 @default.
- W3169586328 hasConceptScore W3169586328C2781290027 @default.
- W3169586328 hasConceptScore W3169586328C71924100 @default.
- W3169586328 hasConceptScore W3169586328C90924648 @default.
- W3169586328 hasIssue "1" @default.
- W3169586328 hasLocation W31695863281 @default.
- W3169586328 hasLocation W31695863282 @default.
- W3169586328 hasLocation W31695863283 @default.
- W3169586328 hasLocation W31695863284 @default.
- W3169586328 hasOpenAccess W3169586328 @default.
- W3169586328 hasPrimaryLocation W31695863281 @default.
- W3169586328 hasRelatedWork W1969455977 @default.
- W3169586328 hasRelatedWork W2002975895 @default.
- W3169586328 hasRelatedWork W2050121444 @default.
- W3169586328 hasRelatedWork W2052900499 @default.
- W3169586328 hasRelatedWork W2148305943 @default.
- W3169586328 hasRelatedWork W2325567551 @default.
- W3169586328 hasRelatedWork W3043108445 @default.
- W3169586328 hasRelatedWork W3169586328 @default.
- W3169586328 hasRelatedWork W4214580355 @default.
- W3169586328 hasRelatedWork W4283710071 @default.
- W3169586328 hasVolume "9" @default.
- W3169586328 isParatext "false" @default.